Pharmacodynamics of the G-Quadruplex-Stabilizing Telomerase Inhibitor 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in Vitro: Activity in Human Tumor Cells Correlates with Telomere Length and Can Be Enhanced, or Antagonized, with Cytotoxic Agents

Telomeric integrity is required to maintain the replicative ability of cancer cells and is a target for the G-quadruplex–stabilizing drug 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4). We report a senescent-like growth arrest in MCF-7 breast cancer cells, within 14...

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Veröffentlicht in:	Molecular pharmacology 2005-12, Vol.68 (6), p.1551-1558
Hauptverfasser:	Cookson, Jennifer C., Dai, Fangping, Smith, Victoria, Heald, Robert A., Laughton, Charles A., Stevens, Malcolm F.G., Burger, Angelika M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacokinetics Acridines - pharmacology Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects DNA DNA-Binding Proteins - antagonists & inhibitors Drug Interactions Enzyme Inhibitors - pharmacology G-Quadruplexes Humans Pharmacokinetics Telomerase - antagonists & inhibitors Telomere - ultrastructure
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