Kaposi's Sarcoma-associated Herpesvirus (KSHV) Oncoprotein K13 Bypasses TRAFs and Directly Interacts with the IκB Kinase Complex to Selectively Activate NF-κB without JNK Activation

Kaposi's sarcoma herpesvirus oncoprotein vFLIP K13 is a potent activator of NF-κB and plays a key role in viral pathogenesis. K13 contains a putative TRAF-interacting motif, which is reportedly required for its interaction with TRAF2. The K13-TRAF2 interaction is believed to be essential for th...

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Veröffentlicht in:	The Journal of biological chemistry 2007-08, Vol.282 (34), p.24858-24865
Hauptverfasser:	Matta, Hittu, Mazzacurati, Lucia, Schamus, Sandra, Yang, Tianbing, Sun, Qinmiao, Chaudhary, Preet M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Kaposi's sarcoma-associated herpesvirus
Online-Zugang:	Volltext
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