Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel

[Display omitted] Current in vitro liver models provide three-dimensional (3-D) microenvironments in combination with tissue engineering technology and can perform more accurate in vivo mimicry than two-dimensional models. However, a human cell-based, functionally mature liver model is still desired...

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Veröffentlicht in:	Acta biomaterialia 2017-12, Vol.64, p.67-79
Hauptverfasser:	Lee, Ho-Joon, Son, Myung Jin, Ahn, Jiwon, Oh, Soo Jin, Lee, Mihee, Kim, Ansoon, Jeung, Yun-Ji, Kim, Han-Gyeul, Won, Misun, Lim, Jung Hwa, Kim, Nam-Soon, Jung, Cho-Rock, Chung, Kyung-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	3-D technology 3D culture Antigens, Differentiation - biosynthesis Biodegradability Biodegradable Plastics - chemistry Biodegradation Biomimetic liver Biomimetics Cell culture Cells, Immobilized - cytology Cells, Immobilized - metabolism Cellular Microenvironment Computer simulation Cytochrome Cytochrome P450 Drug development Drug metabolism Elastic modulus Elasticity Encapsulation Extracellular matrix Gene expression Hepatocyte Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism Humans Hybrid hydrogel Hydrogels Hydrogels - chemistry Liver Liver, Artificial Maturation Mechanical properties Metabolism Microenvironments Mimicry Models, Biological Modulus of elasticity Secretion Semi-interpenetrating networks (Semi-IPNs) Stem cells Three dimensional models Tissue engineering Two dimensional models
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