Lysyl Oxidase Enhances the Deposition of Tropoelastin through the Catalysis of Tropoelastin Molecules on the Cell Surface

The cross-linking of elastin by lysyl oxidase (LOX) family members is essential for the integrity and elasticity of elastic fibers, which play an important role in the characteristic resilience of various tissues. However, the temporal sequence of oxidation by LOX during elastic fiber formation is s...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2017/10/01, Vol.40(10), pp.1646-1653
Hauptverfasser:	Sato, Fumiaki, Seino-Sudo, Ryo, Okada, Mami, Sakai, Hiroyasu, Yumoto, Tetsuro, Wachi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - metabolism Catalysis Cell culture Cell Membrane - metabolism Cell surface Cells, Cultured elastic fiber Elasticity Elastin Enzymatic activity Fibers Fibroblasts - metabolism Fibronectin Flow cytometry Fluorescence HEK293 Cells Humans Immunoblotting Immunofluorescence Liquid oxygen Localization Lysine Lysine - metabolism Lysyl oxidase Microfibrils Oxidation Oxidation-Reduction Protein-Lysine 6-Oxidase - genetics Protein-Lysine 6-Oxidase - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Skin Tissues Tropoelastin Tropoelastin - genetics Tropoelastin - metabolism
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