A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis

Multiple sclerosis (MS) is a human neurodegenerative disease characterized by the invasion of autoreactive T cells from the periphery into the CNS. Application of pan-histone deacetylase inhibitors (HDACi) ameliorates experimental autoimmune encephalomyelitis (EAE), an animal model for MS, suggestin...

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Veröffentlicht in:	Journal of autoimmunity 2018-01, Vol.86, p.51-61
Hauptverfasser:	Göschl, Lisa, Preglej, Teresa, Hamminger, Patricia, Bonelli, Michael, Andersen, Liisa, Boucheron, Nicole, Gülich, Alexandra F., Müller, Lena, Saferding, Victoria, Mufazalov, Ilgiz A., Hirahara, Kiyoshi, Seiser, Christian, Matthias, Patrick, Penz, Thomas, Schuster, Michael, Bock, Christoph, Waisman, Ari, Steiner, Günter, Ellmeier, Wilfried
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity CD4+ T cells Cell Movement Cells, Cultured Chimera Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Experimental autoimmune encephalomyelitis Gene targeting Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histone deacetylases Humans Mice Mice, Knockout Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Receptors, CCR4 - metabolism Receptors, CCR6 - metabolism STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Th17 Cells - physiology
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