EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms

Recently, we reported that the histone methyltransferase, EZH2, controls leukocyte migration through interaction with the cytoskeleton remodeling effector, VAV, and direct methylation of the cytoskeletal regulatory protein, Talin. However, it is unclear whether this extranuclear, epigenetic-independ...

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Veröffentlicht in:	Oncogene 2018-01, Vol.37 (4), p.461-477
Hauptverfasser:	Venkatesan, N, Wong, J F, Tan, K P, Chung, H H, Yau, Y H, Cukuroglu, E, Allahverdi, A, Nordenskiöld, L, Göke, J, Geifman-Shochat, S, Lin, V C L, Madhusudhan, M S, Su, I-h
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/31 14/19 14/35 45/91 631/67/71 82/103 82/83 Apoptosis Cancer Carcinogenesis Cell Biology Cytoplasm Cytoskeletal proteins Cytoskeleton Gene expression Genetic aspects Health aspects Histone methyltransferase Human Genetics Internal Medicine Janus kinase 2 Leukocyte migration Localization Medicine Medicine & Public Health Metastases Methylation Mimicry Oncology original-article Stat3 protein Stem cells Talin Transcription factors Tumorigenesis
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