Impact of the intragastric location of extended release tablets on food interactions

Gastrointestinal motility and transport as well as concomitant food intake are factors that are known to influence pharmacokinetics derived after intake of extended release dosage forms. However, the mechanisms behind these influencing factors are mostly unknown. In this study the gastrointestinal t...

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Veröffentlicht in:	Journal of controlled release 2005-11, Vol.108 (2-3), p.375-385
Hauptverfasser:	Weitschies, Werner, Wedemeyer, Ralph-Steven, Kosch, Olaf, Fach, Kilian, Nagel, Stefan, Söderlind, Erik, Trahms, Lutz, Abrahamsson, Bertil, Mönnikes, Hubert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Algorithms Biological and medical sciences Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - blood Calcium Channel Blockers - pharmacokinetics Colon - metabolism Cross-Over Studies Delayed-Action Preparations Dose dumping Extended release Felodipine Felodipine - administration & dosage Felodipine - blood Felodipine - pharmacokinetics Female Food interactions Food-Drug Interactions Gastric Emptying Gastrointestinal Transit - physiology General pharmacology Humans Magnetic marker monitoring Magnetics Male Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solubility Spectrophotometry, Ultraviolet Stomach - metabolism
Online-Zugang:	Volltext
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