Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy

Successful trials with 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) for Alzheimer's disease treatment prompted renewed interest in assessing whether its therapeutic action is related to the coordination of neurotoxic trace metals, such as Cu(II) and Zn(II). We now report conditional stab...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2007-05, Vol.28 (3), p.445-449
Hauptverfasser:	Ferrada, Evandro, Arancibia, Verónica, Loeb, Bárbara, Norambuena, Ester, Olea-Azar, Claudio, Huidobro-Toro, J. Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - physiology Adult and adolescent clinical studies Algorithms Alzheimer Disease - drug therapy Alzheimer's and Hungtington's diseases Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chemical Phenomena Chemistry, Physical Clioquinol Clioquinol - chemistry Clioquinol - therapeutic use Clioquinol complexes Copper - chemistry Copper - metabolism Cu(II) Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electrophysiology Humans Huntington Disease - drug therapy Ion Channel Gating - drug effects Medical sciences Metals and various inorganic compounds Microinjections Nervous system (semeiology, syndromes) Nervous system as a whole Neurodegenerative diseases Neurology Oocytes - physiology Organic mental disorders. Neuropsychology Oxine Polarography Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Purinergic P2 - genetics Receptors, Purinergic P2X4 Solutions Spectrophotometry, Ultraviolet Toxicology Xenopus laevis Zinc - chemistry Zn(II)
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