An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment
To evaluate brain metabolites in objective insomnia subtypes defined from polysomnography (PSG): insomnia with short sleep duration (I-SSD) and insomnia with normal sleep duration (I-NSD), relative to good sleeping controls (GSCs). PSG empirically grouped insomnia patients into I-SSD (n = 12: mean [...
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| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2017-11, Vol.40 (11) |
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| creator | Miller, Christopher B Rae, Caroline D Green, Michael A Yee, Brendon J Gordon, Christopher J D'Rozario, Angela L Kyle, Simon D Espie, Colin A Grunstein, Ronald R Bartlett, Delwyn J |
| description | To evaluate brain metabolites in objective insomnia subtypes defined from polysomnography (PSG): insomnia with short sleep duration (I-SSD) and insomnia with normal sleep duration (I-NSD), relative to good sleeping controls (GSCs).
PSG empirically grouped insomnia patients into I-SSD (n = 12: mean [SD] total sleep time [TST] = 294.7 minutes [30.5]) or I-NSD (n = 19: TST = 394.4 minutes [34.9]). 1H magnetic resonance spectroscopy (MRS) acquired in the left occipital cortex (LOCC), left prefrontal cortex, and anterior cingulate cortex was used to determine levels of creatine, aspartate, glutamate, and glutamine (referenced to water). Glutathione, glycerophosphocholine, lactate, myoinositol, and N-acetylaspartate measurements were also obtained. Sixteen GSCs were included for comparison. Multivariate analysis of variance was used to evaluate differences in creatine, aspartate, glutamate, and glutamine.
Aspartate and glutamine concentrations were reduced in the LOCC in I-SSD compared with I-NSD (both p < .05, d = .80-.99). Creatine displayed a nonsignificant mean reduction in I-SSD compared with I-NSD (p = .05, d = .58). Glutamine was reduced in I-SSD compared with controls (p < .05, d = .93). There were no differences in metabolites between all (I-SSD and I-NSD) insomnia patients and controls. In patients with insomnia, LOCC glutamine concentrations were found to be positively correlated with TST (r = .43, p < .05) and negatively correlated with wake-time after sleep onset (r = -.40, p < .05).
Results indicate that I-SSD is associated with reduced brain metabolites in the LOCC compared with I-NSD and control concentrations of aspartate, glutamine, and creatine.
Insomnia MRS imaging sleep study: Australia New Zealand Clinical Trials Registry (ANZCTR): https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12612000050853.
12612000050853. |
| doi_str_mv | 10.1093/sleep/zsx148 |
| format | Article |
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PSG empirically grouped insomnia patients into I-SSD (n = 12: mean [SD] total sleep time [TST] = 294.7 minutes [30.5]) or I-NSD (n = 19: TST = 394.4 minutes [34.9]). 1H magnetic resonance spectroscopy (MRS) acquired in the left occipital cortex (LOCC), left prefrontal cortex, and anterior cingulate cortex was used to determine levels of creatine, aspartate, glutamate, and glutamine (referenced to water). Glutathione, glycerophosphocholine, lactate, myoinositol, and N-acetylaspartate measurements were also obtained. Sixteen GSCs were included for comparison. Multivariate analysis of variance was used to evaluate differences in creatine, aspartate, glutamate, and glutamine.
Aspartate and glutamine concentrations were reduced in the LOCC in I-SSD compared with I-NSD (both p < .05, d = .80-.99). Creatine displayed a nonsignificant mean reduction in I-SSD compared with I-NSD (p = .05, d = .58). Glutamine was reduced in I-SSD compared with controls (p < .05, d = .93). There were no differences in metabolites between all (I-SSD and I-NSD) insomnia patients and controls. In patients with insomnia, LOCC glutamine concentrations were found to be positively correlated with TST (r = .43, p < .05) and negatively correlated with wake-time after sleep onset (r = -.40, p < .05).
Results indicate that I-SSD is associated with reduced brain metabolites in the LOCC compared with I-NSD and control concentrations of aspartate, glutamine, and creatine.
Insomnia MRS imaging sleep study: Australia New Zealand Clinical Trials Registry (ANZCTR): https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12612000050853.
12612000050853.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsx148</identifier><identifier>PMID: 28958033</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Brain - metabolism ; Case-Control Studies ; Creatine - metabolism ; Female ; Glutamic Acid - metabolism ; Glutamine - metabolism ; Gyrus Cinguli - metabolism ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Occipital Lobe - metabolism ; Polysomnography ; Prefrontal Cortex - metabolism ; Sleep ; Sleep Initiation and Maintenance Disorders - diagnosis ; Sleep Initiation and Maintenance Disorders - metabolism ; Sleep Initiation and Maintenance Disorders - physiopathology ; Time Factors ; Young Adult</subject><ispartof>Sleep (New York, N.Y.), 2017-11, Vol.40 (11)</ispartof><rights>Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-d82c49dd2b7f86ca2199ac297d78ab61c01010fe6cc04f8dad9c4f183252fbcf3</citedby><cites>FETCH-LOGICAL-c329t-d82c49dd2b7f86ca2199ac297d78ab61c01010fe6cc04f8dad9c4f183252fbcf3</cites><orcidid>0000-0002-2936-7717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28958033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Christopher B</creatorcontrib><creatorcontrib>Rae, Caroline D</creatorcontrib><creatorcontrib>Green, Michael A</creatorcontrib><creatorcontrib>Yee, Brendon J</creatorcontrib><creatorcontrib>Gordon, Christopher J</creatorcontrib><creatorcontrib>D'Rozario, Angela L</creatorcontrib><creatorcontrib>Kyle, Simon D</creatorcontrib><creatorcontrib>Espie, Colin A</creatorcontrib><creatorcontrib>Grunstein, Ronald R</creatorcontrib><creatorcontrib>Bartlett, Delwyn J</creatorcontrib><title>An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>To evaluate brain metabolites in objective insomnia subtypes defined from polysomnography (PSG): insomnia with short sleep duration (I-SSD) and insomnia with normal sleep duration (I-NSD), relative to good sleeping controls (GSCs).
PSG empirically grouped insomnia patients into I-SSD (n = 12: mean [SD] total sleep time [TST] = 294.7 minutes [30.5]) or I-NSD (n = 19: TST = 394.4 minutes [34.9]). 1H magnetic resonance spectroscopy (MRS) acquired in the left occipital cortex (LOCC), left prefrontal cortex, and anterior cingulate cortex was used to determine levels of creatine, aspartate, glutamate, and glutamine (referenced to water). Glutathione, glycerophosphocholine, lactate, myoinositol, and N-acetylaspartate measurements were also obtained. Sixteen GSCs were included for comparison. Multivariate analysis of variance was used to evaluate differences in creatine, aspartate, glutamate, and glutamine.
Aspartate and glutamine concentrations were reduced in the LOCC in I-SSD compared with I-NSD (both p < .05, d = .80-.99). Creatine displayed a nonsignificant mean reduction in I-SSD compared with I-NSD (p = .05, d = .58). Glutamine was reduced in I-SSD compared with controls (p < .05, d = .93). There were no differences in metabolites between all (I-SSD and I-NSD) insomnia patients and controls. In patients with insomnia, LOCC glutamine concentrations were found to be positively correlated with TST (r = .43, p < .05) and negatively correlated with wake-time after sleep onset (r = -.40, p < .05).
Results indicate that I-SSD is associated with reduced brain metabolites in the LOCC compared with I-NSD and control concentrations of aspartate, glutamine, and creatine.
Insomnia MRS imaging sleep study: Australia New Zealand Clinical Trials Registry (ANZCTR): https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12612000050853.
12612000050853.</description><subject>Adult</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Brain - metabolism</subject><subject>Case-Control Studies</subject><subject>Creatine - metabolism</subject><subject>Female</subject><subject>Glutamic Acid - metabolism</subject><subject>Glutamine - metabolism</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Occipital Lobe - metabolism</subject><subject>Polysomnography</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Sleep</subject><subject>Sleep Initiation and Maintenance Disorders - diagnosis</subject><subject>Sleep Initiation and Maintenance Disorders - metabolism</subject><subject>Sleep Initiation and Maintenance Disorders - physiopathology</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kcFu1DAQhq0K1C6FW8-VjxwItZ1k1-5tWSis1KqIhfYYOfakdZXYweNUXV6KV8TLFjSH0Wj--WZGPyEnnL3nTJVn2AOMZ7_wiVfygMx4XbNC5c4LMmN8zgvJWX1EXiE-sFxXqjwkR0KqWrKynJHfS0-v2wcwyT0C3dyHmOhmR6Rrj2HwTtOPDkO0EOlmatN2BLpGukQMxukElt66dE-_gZ1MLj5E7Ty9gqTb0LsEdBW8AZ-iTi54zFB64x7DOV3SrxF6Nziv45Ze6TsPyZnMweB1HqGbMd8UA5owbnfrAHHIoNfkZad7hDfP-Zj8uPj0ffWluLz-vF4tLwtTCpUKK4WplLWiXXRybrTgSmkj1MIupG7n3DCeo4O5MazqpNVWmarjshS16FrTlcfk7Z47xvBzAkzN4NBA32sPYcKGq6oWXDKlsvTdXmryuRiha8bohvxWw1mzs6j5a1GztyjLT5_JUzuA_S_-50n5B2ZNkuY</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Miller, Christopher B</creator><creator>Rae, Caroline D</creator><creator>Green, Michael A</creator><creator>Yee, Brendon J</creator><creator>Gordon, Christopher J</creator><creator>D'Rozario, Angela L</creator><creator>Kyle, Simon D</creator><creator>Espie, Colin A</creator><creator>Grunstein, Ronald R</creator><creator>Bartlett, Delwyn J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2936-7717</orcidid></search><sort><creationdate>20171101</creationdate><title>An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment</title><author>Miller, Christopher B ; Rae, Caroline D ; Green, Michael A ; Yee, Brendon J ; Gordon, Christopher J ; D'Rozario, Angela L ; Kyle, Simon D ; Espie, Colin A ; Grunstein, Ronald R ; Bartlett, Delwyn J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-d82c49dd2b7f86ca2199ac297d78ab61c01010fe6cc04f8dad9c4f183252fbcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Brain - metabolism</topic><topic>Case-Control Studies</topic><topic>Creatine - metabolism</topic><topic>Female</topic><topic>Glutamic Acid - metabolism</topic><topic>Glutamine - metabolism</topic><topic>Gyrus Cinguli - metabolism</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Occipital Lobe - metabolism</topic><topic>Polysomnography</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Sleep</topic><topic>Sleep Initiation and Maintenance Disorders - diagnosis</topic><topic>Sleep Initiation and Maintenance Disorders - metabolism</topic><topic>Sleep Initiation and Maintenance Disorders - physiopathology</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Christopher B</creatorcontrib><creatorcontrib>Rae, Caroline D</creatorcontrib><creatorcontrib>Green, Michael A</creatorcontrib><creatorcontrib>Yee, Brendon J</creatorcontrib><creatorcontrib>Gordon, Christopher J</creatorcontrib><creatorcontrib>D'Rozario, Angela L</creatorcontrib><creatorcontrib>Kyle, Simon D</creatorcontrib><creatorcontrib>Espie, Colin A</creatorcontrib><creatorcontrib>Grunstein, Ronald R</creatorcontrib><creatorcontrib>Bartlett, Delwyn J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Christopher B</au><au>Rae, Caroline D</au><au>Green, Michael A</au><au>Yee, Brendon J</au><au>Gordon, Christopher J</au><au>D'Rozario, Angela L</au><au>Kyle, Simon D</au><au>Espie, Colin A</au><au>Grunstein, Ronald R</au><au>Bartlett, Delwyn J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>40</volume><issue>11</issue><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>To evaluate brain metabolites in objective insomnia subtypes defined from polysomnography (PSG): insomnia with short sleep duration (I-SSD) and insomnia with normal sleep duration (I-NSD), relative to good sleeping controls (GSCs).
PSG empirically grouped insomnia patients into I-SSD (n = 12: mean [SD] total sleep time [TST] = 294.7 minutes [30.5]) or I-NSD (n = 19: TST = 394.4 minutes [34.9]). 1H magnetic resonance spectroscopy (MRS) acquired in the left occipital cortex (LOCC), left prefrontal cortex, and anterior cingulate cortex was used to determine levels of creatine, aspartate, glutamate, and glutamine (referenced to water). Glutathione, glycerophosphocholine, lactate, myoinositol, and N-acetylaspartate measurements were also obtained. Sixteen GSCs were included for comparison. Multivariate analysis of variance was used to evaluate differences in creatine, aspartate, glutamate, and glutamine.
Aspartate and glutamine concentrations were reduced in the LOCC in I-SSD compared with I-NSD (both p < .05, d = .80-.99). Creatine displayed a nonsignificant mean reduction in I-SSD compared with I-NSD (p = .05, d = .58). Glutamine was reduced in I-SSD compared with controls (p < .05, d = .93). There were no differences in metabolites between all (I-SSD and I-NSD) insomnia patients and controls. In patients with insomnia, LOCC glutamine concentrations were found to be positively correlated with TST (r = .43, p < .05) and negatively correlated with wake-time after sleep onset (r = -.40, p < .05).
Results indicate that I-SSD is associated with reduced brain metabolites in the LOCC compared with I-NSD and control concentrations of aspartate, glutamine, and creatine.
Insomnia MRS imaging sleep study: Australia New Zealand Clinical Trials Registry (ANZCTR): https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12612000050853.
12612000050853.</abstract><cop>United States</cop><pmid>28958033</pmid><doi>10.1093/sleep/zsx148</doi><orcidid>https://orcid.org/0000-0002-2936-7717</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Brain - metabolism Case-Control Studies Creatine - metabolism Female Glutamic Acid - metabolism Glutamine - metabolism Gyrus Cinguli - metabolism Humans Magnetic Resonance Spectroscopy Male Middle Aged Occipital Lobe - metabolism Polysomnography Prefrontal Cortex - metabolism Sleep Sleep Initiation and Maintenance Disorders - diagnosis Sleep Initiation and Maintenance Disorders - metabolism Sleep Initiation and Maintenance Disorders - physiopathology Time Factors Young Adult |
| title | An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment |
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