Gene expression analysis of Arc mRNA as a neuronal cell activity marker in the hippocampus and amygdala in two-way active avoidance test in rats

Immediate early genes are widely used as neuronal cell activity markers in neuroscience. The present study investigated the relationship between their expression and abnormality in context fear conditioning. The learning test (two-way active avoidance test) was conducted in male rats administered wi...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2017-11, Vol.88 (Pt 2), p.140-146
Hauptverfasser:	Yasuno, Kyohei, Takahashi, Erika, Igarashi, Isao, Iguchi, Takuma, Tsuchiya, Yoshimi, Kai, Kiyonori, Mori, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - drug effects Amygdala - metabolism Animals Arc Avoidance Learning - drug effects Avoidance Learning - physiology Benzazepines - pharmacology Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - genetics Fear - drug effects Fear - physiology Fos Gene Expression Genes, Immediate-Early - drug effects Genes, Immediate-Early - physiology Hippocampus - drug effects Hippocampus - metabolism Immediate early gene Male Muscarinic Antagonists - pharmacology Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurons - drug effects Neurons - metabolism Rat Rats Rats, Inbred F344 Rats, Sprague-Dawley Receptors, Dopamine D1 - antagonists & inhibitors RNA, Messenger - biosynthesis RNA, Messenger - genetics SCH 23390 Scopolamine Scopolamine Hydrobromide - pharmacology Two-way active avoidance test
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