Large Amino Acid Transporter 1 Selective Liposomes of l‑DOPA Functionalized Amphiphile for Combating Glioblastoma

Despite significant progress in neurosurgery and radiation therapy during the past decade, overall survivability (OS) of glioblastoma patients continues to be less than 2 years. The scope of systemic chemotherapy is greatly limited by poor drug transport across the blood brain barrier (BBB) and, the...

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Veröffentlicht in:	Molecular pharmaceutics 2017-11, Vol.14 (11), p.3834-3847
Hauptverfasser:	Bhunia, Sukanya, Vangala, Venugopal, Bhattacharya, Dwaipayan, Ravuri, Halley Gora, Kuncha, Madhusudana, Chakravarty, Sumana, Sistla, Ramakrishna, Chaudhuri, Arabinda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - genetics Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blotting, Western Brain Neoplasms - metabolism Brain Neoplasms - therapy Cell Cycle Checkpoints - drug effects Cell Cycle Checkpoints - genetics Cell Line, Tumor Female Flow Cytometry Glioblastoma - metabolism Glioblastoma - therapy Large Neutral Amino Acid-Transporter 1 - genetics Large Neutral Amino Acid-Transporter 1 - metabolism Levodopa - chemistry Liposomes - chemistry Mice Mice, Inbred C57BL Spectrometry, Mass, Electrospray Ionization
Online-Zugang:	Volltext
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