HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer

The current study aims to investigate the biological roles and clinical significance of HCRP1 in human gastric cancer. The expression pattern of HCRP1 in gastric cancer tissue and adjacent non-cancerous tissue was detected by immunohistochemistry. HCRP1 downregulation was found in 57 of 137 human ga...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2017-12, Vol.471 (6), p.743-751
Hauptverfasser:	Xu, Hao, Miao, Zhi-Feng, Wang, Zhen-Ning, Zhao, Ting-Ting, Xu, Ying-Ying, Song, Yong-Xi, Huang, Jin-Yu, Zhang, Jun-Yan, Liu, Xing-Yu, Wu, Jian-Hua, Xu, Hui-Mian
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Annexin V Cancer Cell proliferation Chemoresistance Cisplatin Colonies Cyclin D1 Depletion Drug resistance Epidermal growth factor receptors Gastric cancer Gelatinase A Immunohistochemistry Medical prognosis Medicine Medicine & Public Health Original Article Pathology Prognosis Ribonucleic acid RNA Signaling siRNA Survival
Online-Zugang:	Volltext
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