Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine a-induced nephrotoxicity in rats

Ellagic acid (EA), a dietary antioxidant associated with poor biopharmaceutical properties, was encapsulated into poly(lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) nanoparticles to improve oral bioavailability. EA-loaded nanoparticles were prepared following emulsion-diffusion-evaporation...

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Veröffentlicht in:	Pharmaceutical research 2007-05, Vol.24 (5), p.899-908
Hauptverfasser:	SONAJE, K, ITALIA, J. L, SHARMA, G, BHARDWAJ, V, TIKOO, K, RAVI KUMAR, M. N. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Ammonium Animals Antioxidants Antioxidants - administration & dosage Antioxidants - pharmacokinetics Antioxidants - therapeutic use Bioavailability Biocompatible Materials - chemistry Biodegradation Biological and medical sciences Biological Availability Biopharmaceuticals Carboxymethylcellulose Cellulose Cyclosporine - administration & dosage Cyclosporine - toxicity Cyclosporins Diffusion Drug Compounding - methods Drug dosages Ellagic acid Ellagic Acid - chemistry Ellagic Acid - pharmacokinetics Ellagic Acid - therapeutic use Encapsulation Evaporation General pharmacology Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - toxicity Kidney Diseases - chemically induced Kidney Diseases - drug therapy Kidney Diseases - pathology Kidneys Lactic Acid - chemistry Male Medical sciences Microscopy, Polarization - methods Nanoparticles Nanoparticles - chemistry Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology Pharmacology. Drug treatments Poly(lactide-co-glycolide) Polycaprolactone Polyesters - chemistry Polyethylene Glycols - chemistry Polyglycolic Acid - chemistry Polylactic Acid-Polyglycolic Acid Copolymer Polylactide-co-glycolide Polymers - chemistry Polyvinyl alcohol Polyvinyl Alcohol - chemistry Rats Rats, Sprague-Dawley Rodents Treatment Outcome
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