Magnetic resonance guided renal denervation using active tracking: first in vivo experience in Swine
Interventional cardiovascular magnetic resonance (iCMR) might evolve as a technique to improve procedural success rates in cardiovascular interventions by combining intraprocedural guidance and simultaneous lesion imaging. The objective of the present study was to prove feasibility and estimate safe...
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Veröffentlicht in: | The International Journal of Cardiovascular Imaging 2018-03, Vol.34 (3), p.431-439 |
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description | Interventional cardiovascular magnetic resonance (iCMR) might evolve as a technique to improve procedural success rates in cardiovascular interventions by combining intraprocedural guidance and simultaneous lesion imaging. The objective of the present study was to prove feasibility and estimate safety of renal sympathetic denervation guided by real-time iCMR using active tracking. Six pigs were examined in a 1.5 T MRI-System (Achieva, Philips Healthcare, Best, Netherlands) equipped with non-invasive hemodynamic control and in-room monitors displaying an interventional software platform [Interventional MRI Suite (iSuite), Philips Research, Hamburg, Germany]. MR-guided renal denervation was performed using a MR conditional non-irrigated ablation catheter with active tracking (Imricor, Burnsville, MN, USA). Real-time imaging for device guidance was performed with a TFE sequence, vessel patency was assessed with a 3D non-contrast angiography and velocity encoded imaging. Oedema of the renal artery was visualized by a high-resolution T2 SPIR sequence. Renal sympathetic denervation was feasible in all cases with survival of all animals. Non-contrast angiography displayed renal artery patency accompanied by equal flow conditions before and after the ablation in all cases as measured by velocity encoded imaging. Oedema imaging displayed a significant increase in relative signal intensity at renal artery ablations sites pre and post intervention (p |
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The objective of the present study was to prove feasibility and estimate safety of renal sympathetic denervation guided by real-time iCMR using active tracking. Six pigs were examined in a 1.5 T MRI-System (Achieva, Philips Healthcare, Best, Netherlands) equipped with non-invasive hemodynamic control and in-room monitors displaying an interventional software platform [Interventional MRI Suite (iSuite), Philips Research, Hamburg, Germany]. MR-guided renal denervation was performed using a MR conditional non-irrigated ablation catheter with active tracking (Imricor, Burnsville, MN, USA). Real-time imaging for device guidance was performed with a TFE sequence, vessel patency was assessed with a 3D non-contrast angiography and velocity encoded imaging. Oedema of the renal artery was visualized by a high-resolution T2 SPIR sequence. Renal sympathetic denervation was feasible in all cases with survival of all animals. Non-contrast angiography displayed renal artery patency accompanied by equal flow conditions before and after the ablation in all cases as measured by velocity encoded imaging. Oedema imaging displayed a significant increase in relative signal intensity at renal artery ablations sites pre and post intervention (p < 0.05). The histologic examination revealed no signs of perforation or bleeding, while sufficient ablation lesions could be depicted. MR-guided renal sympathetic denervation using active tracking is feasible and the initial data suggest safety of this procedure. MR-guided renal sympathetic denervation offers the inherent strength of high soft tissue contrast thereby providing target information without the use of iodinated contrast agents or radiation.</description><identifier>ISSN: 1569-5794</identifier><identifier>EISSN: 1573-0743</identifier><identifier>EISSN: 1875-8312</identifier><identifier>DOI: 10.1007/s10554-017-1244-6</identifier><identifier>PMID: 28956200</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Ablation ; Angiography ; Animals ; Biopsy ; Bleeding ; Cardiac Imaging ; Cardiology ; Catheter Ablation - adverse effects ; Coding ; Contrast agents ; Denervation ; Edema ; Feasibility Studies ; Health care ; Image Interpretation, Computer-Assisted ; Imaging ; Kidney - blood supply ; Kidneys ; Lesions ; Livestock ; Magnetic resonance imaging ; Magnetic Resonance Imaging, Interventional - adverse effects ; Medical imaging ; Medical instruments ; Medicine ; Medicine & Public Health ; Models, Animal ; Original Paper ; Perforation ; Radiation ; Radiology ; Real time ; Renal artery ; Renal Artery - diagnostic imaging ; Renal Artery - innervation ; Renal Artery - pathology ; Resonance ; Safety ; Swine ; Swine, Miniature ; Sympathectomy - adverse effects ; Sympathectomy - methods ; Sympathetic Nervous System - surgery ; Time Factors ; Tracking ; Veins & arteries ; Velocity</subject><ispartof>The International Journal of Cardiovascular Imaging, 2018-03, Vol.34 (3), p.431-439</ispartof><rights>Springer Science+Business Media B.V. 2017</rights><rights>The International Journal of Cardiovascular Imaging is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-4bb16a1e4ff2c12e98ea160733458bd05290fabb1d03183b33ff4a2dedd9df3e3</citedby><cites>FETCH-LOGICAL-c372t-4bb16a1e4ff2c12e98ea160733458bd05290fabb1d03183b33ff4a2dedd9df3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10554-017-1244-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10554-017-1244-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28956200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bönner, F.</creatorcontrib><creatorcontrib>Haberkorn, S.</creatorcontrib><creatorcontrib>Behm, P.</creatorcontrib><creatorcontrib>Schnackenburg, B.</creatorcontrib><creatorcontrib>Krüger, S.</creatorcontrib><creatorcontrib>Weiss, S.</creatorcontrib><creatorcontrib>Meyer, C.</creatorcontrib><creatorcontrib>Kelm, M.</creatorcontrib><creatorcontrib>Neizel-Wittke, M.</creatorcontrib><title>Magnetic resonance guided renal denervation using active tracking: first in vivo experience in Swine</title><title>The International Journal of Cardiovascular Imaging</title><addtitle>Int J Cardiovasc Imaging</addtitle><addtitle>Int J Cardiovasc Imaging</addtitle><description>Interventional cardiovascular magnetic resonance (iCMR) might evolve as a technique to improve procedural success rates in cardiovascular interventions by combining intraprocedural guidance and simultaneous lesion imaging. The objective of the present study was to prove feasibility and estimate safety of renal sympathetic denervation guided by real-time iCMR using active tracking. Six pigs were examined in a 1.5 T MRI-System (Achieva, Philips Healthcare, Best, Netherlands) equipped with non-invasive hemodynamic control and in-room monitors displaying an interventional software platform [Interventional MRI Suite (iSuite), Philips Research, Hamburg, Germany]. MR-guided renal denervation was performed using a MR conditional non-irrigated ablation catheter with active tracking (Imricor, Burnsville, MN, USA). Real-time imaging for device guidance was performed with a TFE sequence, vessel patency was assessed with a 3D non-contrast angiography and velocity encoded imaging. Oedema of the renal artery was visualized by a high-resolution T2 SPIR sequence. Renal sympathetic denervation was feasible in all cases with survival of all animals. Non-contrast angiography displayed renal artery patency accompanied by equal flow conditions before and after the ablation in all cases as measured by velocity encoded imaging. Oedema imaging displayed a significant increase in relative signal intensity at renal artery ablations sites pre and post intervention (p < 0.05). The histologic examination revealed no signs of perforation or bleeding, while sufficient ablation lesions could be depicted. MR-guided renal sympathetic denervation using active tracking is feasible and the initial data suggest safety of this procedure. MR-guided renal sympathetic denervation offers the inherent strength of high soft tissue contrast thereby providing target information without the use of iodinated contrast agents or radiation.</description><subject>Ablation</subject><subject>Angiography</subject><subject>Animals</subject><subject>Biopsy</subject><subject>Bleeding</subject><subject>Cardiac Imaging</subject><subject>Cardiology</subject><subject>Catheter Ablation - adverse effects</subject><subject>Coding</subject><subject>Contrast agents</subject><subject>Denervation</subject><subject>Edema</subject><subject>Feasibility Studies</subject><subject>Health care</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Imaging</subject><subject>Kidney - blood supply</subject><subject>Kidneys</subject><subject>Lesions</subject><subject>Livestock</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging, Interventional - adverse effects</subject><subject>Medical imaging</subject><subject>Medical instruments</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Models, Animal</subject><subject>Original Paper</subject><subject>Perforation</subject><subject>Radiation</subject><subject>Radiology</subject><subject>Real time</subject><subject>Renal artery</subject><subject>Renal Artery - diagnostic imaging</subject><subject>Renal Artery - innervation</subject><subject>Renal Artery - pathology</subject><subject>Resonance</subject><subject>Safety</subject><subject>Swine</subject><subject>Swine, Miniature</subject><subject>Sympathectomy - adverse effects</subject><subject>Sympathectomy - methods</subject><subject>Sympathetic Nervous System - surgery</subject><subject>Time Factors</subject><subject>Tracking</subject><subject>Veins & arteries</subject><subject>Velocity</subject><issn>1569-5794</issn><issn>1573-0743</issn><issn>1875-8312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kctO3DAUhi1UxK08ABtkqZtuUo4viWN2CLWlEogFdG058fHI0xlnaicDvD0ezZRKSKxsH3_nP5efkDMG3xiAusgM6lpWwFTFuJRVs0eOWK1EBUqKT5t7o6taaXlIjnOeAwAHLg7IIW913XCAI-Lu7CziGHqaMA_Rxh7pbAoOXQlEu6AOI6a1HcMQ6ZRDnFHbj2GNdEy2_1Pel9SHlEcaIl2H9UDxeYUp4EaohB6eQsTPZN_bRcbT3XlCfv_4_nh9U93e__x1fXVb9ULxsZJdxxrLUHrPe8ZRt2hZA0oIWbedg5pr8LZADgRrRSeE99Ly0qvTzgsUJ-TrVneVhr8T5tEsQ-5xsbARhykbpqWUoq2lLuiXd-h8mFIZOJuyF6UVNEwVim2pPg05J_RmlcLSphfDwGwsMFsLTLHAbCwwTck53ylP3RLdW8a_nReAb4FcvuIM0__SH6u-ArmZkeo</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Bönner, F.</creator><creator>Haberkorn, S.</creator><creator>Behm, P.</creator><creator>Schnackenburg, B.</creator><creator>Krüger, S.</creator><creator>Weiss, S.</creator><creator>Meyer, C.</creator><creator>Kelm, M.</creator><creator>Neizel-Wittke, M.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Magnetic resonance guided renal denervation using active tracking: first in vivo experience in Swine</title><author>Bönner, F. ; Haberkorn, S. ; Behm, P. ; Schnackenburg, B. ; Krüger, S. ; Weiss, S. ; Meyer, C. ; Kelm, M. ; Neizel-Wittke, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-4bb16a1e4ff2c12e98ea160733458bd05290fabb1d03183b33ff4a2dedd9df3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ablation</topic><topic>Angiography</topic><topic>Animals</topic><topic>Biopsy</topic><topic>Bleeding</topic><topic>Cardiac Imaging</topic><topic>Cardiology</topic><topic>Catheter Ablation - adverse effects</topic><topic>Coding</topic><topic>Contrast agents</topic><topic>Denervation</topic><topic>Edema</topic><topic>Feasibility Studies</topic><topic>Health care</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Imaging</topic><topic>Kidney - blood supply</topic><topic>Kidneys</topic><topic>Lesions</topic><topic>Livestock</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging, Interventional - adverse effects</topic><topic>Medical imaging</topic><topic>Medical instruments</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Models, Animal</topic><topic>Original Paper</topic><topic>Perforation</topic><topic>Radiation</topic><topic>Radiology</topic><topic>Real time</topic><topic>Renal artery</topic><topic>Renal Artery - diagnostic imaging</topic><topic>Renal Artery - innervation</topic><topic>Renal Artery - pathology</topic><topic>Resonance</topic><topic>Safety</topic><topic>Swine</topic><topic>Swine, Miniature</topic><topic>Sympathectomy - adverse effects</topic><topic>Sympathectomy - methods</topic><topic>Sympathetic Nervous System - surgery</topic><topic>Time Factors</topic><topic>Tracking</topic><topic>Veins & arteries</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bönner, F.</creatorcontrib><creatorcontrib>Haberkorn, S.</creatorcontrib><creatorcontrib>Behm, P.</creatorcontrib><creatorcontrib>Schnackenburg, B.</creatorcontrib><creatorcontrib>Krüger, S.</creatorcontrib><creatorcontrib>Weiss, S.</creatorcontrib><creatorcontrib>Meyer, C.</creatorcontrib><creatorcontrib>Kelm, M.</creatorcontrib><creatorcontrib>Neizel-Wittke, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The International Journal of Cardiovascular Imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bönner, F.</au><au>Haberkorn, S.</au><au>Behm, P.</au><au>Schnackenburg, B.</au><au>Krüger, S.</au><au>Weiss, S.</au><au>Meyer, C.</au><au>Kelm, M.</au><au>Neizel-Wittke, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance guided renal denervation using active tracking: first in vivo experience in Swine</atitle><jtitle>The International Journal of Cardiovascular Imaging</jtitle><stitle>Int J Cardiovasc Imaging</stitle><addtitle>Int J Cardiovasc Imaging</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>34</volume><issue>3</issue><spage>431</spage><epage>439</epage><pages>431-439</pages><issn>1569-5794</issn><eissn>1573-0743</eissn><eissn>1875-8312</eissn><abstract>Interventional cardiovascular magnetic resonance (iCMR) might evolve as a technique to improve procedural success rates in cardiovascular interventions by combining intraprocedural guidance and simultaneous lesion imaging. The objective of the present study was to prove feasibility and estimate safety of renal sympathetic denervation guided by real-time iCMR using active tracking. Six pigs were examined in a 1.5 T MRI-System (Achieva, Philips Healthcare, Best, Netherlands) equipped with non-invasive hemodynamic control and in-room monitors displaying an interventional software platform [Interventional MRI Suite (iSuite), Philips Research, Hamburg, Germany]. MR-guided renal denervation was performed using a MR conditional non-irrigated ablation catheter with active tracking (Imricor, Burnsville, MN, USA). Real-time imaging for device guidance was performed with a TFE sequence, vessel patency was assessed with a 3D non-contrast angiography and velocity encoded imaging. Oedema of the renal artery was visualized by a high-resolution T2 SPIR sequence. Renal sympathetic denervation was feasible in all cases with survival of all animals. Non-contrast angiography displayed renal artery patency accompanied by equal flow conditions before and after the ablation in all cases as measured by velocity encoded imaging. Oedema imaging displayed a significant increase in relative signal intensity at renal artery ablations sites pre and post intervention (p < 0.05). The histologic examination revealed no signs of perforation or bleeding, while sufficient ablation lesions could be depicted. MR-guided renal sympathetic denervation using active tracking is feasible and the initial data suggest safety of this procedure. MR-guided renal sympathetic denervation offers the inherent strength of high soft tissue contrast thereby providing target information without the use of iodinated contrast agents or radiation.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>28956200</pmid><doi>10.1007/s10554-017-1244-6</doi><tpages>9</tpages></addata></record> |
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subjects | Ablation Angiography Animals Biopsy Bleeding Cardiac Imaging Cardiology Catheter Ablation - adverse effects Coding Contrast agents Denervation Edema Feasibility Studies Health care Image Interpretation, Computer-Assisted Imaging Kidney - blood supply Kidneys Lesions Livestock Magnetic resonance imaging Magnetic Resonance Imaging, Interventional - adverse effects Medical imaging Medical instruments Medicine Medicine & Public Health Models, Animal Original Paper Perforation Radiation Radiology Real time Renal artery Renal Artery - diagnostic imaging Renal Artery - innervation Renal Artery - pathology Resonance Safety Swine Swine, Miniature Sympathectomy - adverse effects Sympathectomy - methods Sympathetic Nervous System - surgery Time Factors Tracking Veins & arteries Velocity |
title | Magnetic resonance guided renal denervation using active tracking: first in vivo experience in Swine |
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