Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages

Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages

In this study, we designed NO-activatable gold nanoparticles (NAM-AuNPs) for specific targeting and photo-thermal ablation of macrophages. The gold nanoparticles showed aggregation behavior in response to NO solution as well as endogenous NO secreted from activated macrophages. Following NIR irradia...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2017-10, Vol.53 (81), p.11229-11232
Hauptverfasser: Park, Junghong, Pramanick, Swapan, Kim, Jinhwan, Lee, Jihyun, Kim, Won Jong
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Survival - drug effects
Dose-Response Relationship, Drug
Gold - chemistry
Gold - pharmacology
Lipopolysaccharides - pharmacology
Macrophages - drug effects
Metal Nanoparticles - chemistry
Mice
Molecular Structure
NIH 3T3 Cells
Nitric Oxide - biosynthesis
Nitric Oxide - chemistry
Nitric Oxide - pharmacology
Particle Size
Phototherapy
RAW 264.7 Cells
Structure-Activity Relationship
Temperature
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Zusammenfassung:In this study, we designed NO-activatable gold nanoparticles (NAM-AuNPs) for specific targeting and photo-thermal ablation of macrophages. The gold nanoparticles showed aggregation behavior in response to NO solution as well as endogenous NO secreted from activated macrophages. Following NIR irradiation, significant cytotoxicity was observed in activated RAW 264.7 cells treated with NAM-AuNPs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc06420a