Subtoxic concentrations of allergenic haptens induce LC migration and maturation in a human organotypic skin explant culture model: a novel method for identifying potential contact allergens

: The accelerated migration of Langerhans cells (LCs) out of the epidermis and up‐regulation of maturation markers, upon treatment with subtoxic concentrations of chemicals, were used as the criteria to determine the potential of allergenic chemicals capable of inducing a hapten‐specific delayed‐ty...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental dermatology 2006-06, Vol.15 (6), p.421-431
Hauptverfasser:	Lehé, Cynthia L., Jacobs, John J. L., Hua, Chi Mei, Courtellemont, P, Elliott, Graham R., Das, Pranab K.
Format:	Artikel
Sprache:	eng
Schlagworte:	activation markers allergen Allergens - administration & dosage Allergens - toxicity Antigens, CD - metabolism Biological and medical sciences CD83 Antigen Cell Differentiation - drug effects Cell Movement - drug effects Dermatitis, Allergic Contact - etiology Dermatitis, Allergic Contact - immunology Dermatitis, Allergic Contact - pathology Dermatology Haptens - administration & dosage Haptens - toxicity HOSEC Humans Immunoglobulins - metabolism Langerhans cell Langerhans Cells - drug effects Langerhans Cells - pathology Langerhans Cells - physiology Medical sciences Membrane Glycoproteins - metabolism migration Models, Biological Skin - drug effects Skin - pathology Skin - physiopathology Tissue Culture Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!