Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator

Metabolic reduction can be used to activate prodrugs in hypoxic regions of tumours, but reduction by ionising radiation is also theoretically attractive. Previously, we showed that a cobalt(III) complex containing 8-hydroxyquinoline (8-HQ) and cyclen ligands releases 8-HQ efficiently on irradiation...

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Veröffentlicht in:	Biochemical pharmacology 2006-06, Vol.71 (12), p.1683-1694
Hauptverfasser:	Ahn, G-One, Botting, K. Jane, Patterson, Adam V., Ware, David C., Tercel, Moana, Wilson, William R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacokinetics Alkylating Agents - pharmacology Azo Compounds - pharmacokinetics Azo Compounds - pharmacology Biological and medical sciences Biotransformation CBI Cell Hypoxia Chromatography, High Pressure Liquid Co(III) complex Cobalt - chemistry DNA minor groove alkylator HT29 Cells Humans Indoles - pharmacokinetics Indoles - pharmacology Ionising radiation Mass Spectrometry Medical sciences Pharmacology. Drug treatments Prodrug Prodrugs - chemistry Radiation, Ionizing Tumour hypoxia
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