Using TEM to couple transient protein distribution and release for PLGA microparticles for potential use as vaccine delivery vehicles

In the development of tunable PLGA microparticles as vaccine delivery vehicles, it is important to understand the drug distribution within the microparticle over time as well as the long-term release of the drug during polymer degradation. This study addresses the transient 3-D drug distribution in...

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Veröffentlicht in:	Journal of controlled release 2006-06, Vol.113 (1), p.15-22
Hauptverfasser:	Zhao, Aiying, Rodgers, V.G.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradable microparticles Biological and medical sciences Delayed-Action Preparations Drug Carriers Drug Delivery Systems General pharmacology Lactic Acid - chemistry Lactic Acid - pharmacokinetics Medical sciences Microscopy, Electron, Scanning Microspheres Ovalbumin Ovalbumin - chemistry Ovalbumin - pharmacokinetics Ovalbumin - ultrastructure Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLGA Polyglycolic Acid - chemistry Polyglycolic Acid - pharmacokinetics Polymer degradation Polymer erosion Polymers - chemistry Polymers - pharmacokinetics Protein distribution Protein release Time Factors Time-dependent Tissue Distribution Transient release Transmission electron microscopy (TEM) Vaccines - chemistry Vaccines - pharmacokinetics
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