Sub-acute neuropathy in patients with African tick bite fever
African tick bite fever (ATBF) caused by Rickettsia africae is an emerging health problem in travellers to sub-Saharan Africa. We here present 6 patients with evidence of long-lasting sub-acute neuropathy following ATBF contracted during safari trips to southern Africa. Three patients developed radi...
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| Veröffentlicht in: | Scandinavian journal of infectious diseases 2006, Vol.38 (2), p.114-118 |
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| container_title | Scandinavian journal of infectious diseases |
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| creator | Jensenius, Mogens Fournier, Pierre-Edouard Fladby, Tormod Block Hellum, Kjell Hagen, Tormod Priø, Tine Skovdal Christiansen, Merete Vene, Sirkka Raoult, Didier Myrvang, Bjørn |
| description | African tick bite fever (ATBF) caused by Rickettsia africae is an emerging health problem in travellers to sub-Saharan Africa. We here present 6 patients with evidence of long-lasting sub-acute neuropathy following ATBF contracted during safari trips to southern Africa. Three patients developed radiating pain, paresthaesia and/or motor weakness of extremities, 2 had hemi-facial pain and paresthaesia, and 1 developed unilateral sensorineural hearing loss. When evaluated 3-26 months after symptom onset, cerebrospinal fluid samples from 5 patients were negative for R. africae PCR and serology, but revealed elevated protein content in 3 and mild pleocytosis in 1 case. Despite extensive investigations, no plausible alternative causes of neuropathy could be identified. Treatment with doxycycline in 2 patients had no clinical effect. Given the current increase of international safari tourism to sub-Saharan Africa, more cases of sub-acute neuropathy following ATBF may well be encountered in Europe and elsewhere in the y to come. |
| doi_str_mv | 10.1080/00365540500321579 |
| format | Article |
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We here present 6 patients with evidence of long-lasting sub-acute neuropathy following ATBF contracted during safari trips to southern Africa. Three patients developed radiating pain, paresthaesia and/or motor weakness of extremities, 2 had hemi-facial pain and paresthaesia, and 1 developed unilateral sensorineural hearing loss. When evaluated 3-26 months after symptom onset, cerebrospinal fluid samples from 5 patients were negative for R. africae PCR and serology, but revealed elevated protein content in 3 and mild pleocytosis in 1 case. Despite extensive investigations, no plausible alternative causes of neuropathy could be identified. Treatment with doxycycline in 2 patients had no clinical effect. 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We here present 6 patients with evidence of long-lasting sub-acute neuropathy following ATBF contracted during safari trips to southern Africa. Three patients developed radiating pain, paresthaesia and/or motor weakness of extremities, 2 had hemi-facial pain and paresthaesia, and 1 developed unilateral sensorineural hearing loss. When evaluated 3-26 months after symptom onset, cerebrospinal fluid samples from 5 patients were negative for R. africae PCR and serology, but revealed elevated protein content in 3 and mild pleocytosis in 1 case. Despite extensive investigations, no plausible alternative causes of neuropathy could be identified. Treatment with doxycycline in 2 patients had no clinical effect. 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| ispartof | Scandinavian journal of infectious diseases, 2006, Vol.38 (2), p.114-118 |
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| source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Adult Bacterial diseases Biological and medical sciences Female Human bacterial diseases Humans Infectious diseases Ixodidae Male Medical sciences Middle Aged Nervous System Diseases - diagnosis Nervous System Diseases - etiology Nervous System Diseases - physiopathology Rickettsia africae Rickettsia Infections - complications Rickettsia Infections - physiopathology Rickettsial diseases South Africa Time Factors Travel Tropical bacterial diseases |
| title | Sub-acute neuropathy in patients with African tick bite fever |
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