Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl- l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes

Previously we have shown that 90% of streptozotocin (STZ)-induced type-1 diabetic (DB) mice survive from acute renal failure (ARF) and death induced by a normally LD 90 dose (75 mg/kg, i.p.) of the nephrotoxicant S-1,2-dichlorovinyl- l-cysteine (DCVC). This remarkable protection is due to a combinat...

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