Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property
A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly( l-lysine) block copolymers (PEG- b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited...
Gespeichert in:
| Veröffentlicht in: | Journal of controlled release 2006-06, Vol.113 (1), p.73-79 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 79 |
|---|---|
| container_issue | 1 |
| container_start_page | 73 |
| container_title | Journal of controlled release |
| container_volume | 113 |
| creator | Jang, Woo-Dong Nakagishi, Yoshinori Nishiyama, Nobuhiro Kawauchi, Satoko Morimoto, Yuji Kikuchi, Makoto Kataoka, Kazunori |
| description | A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly(
l-lysine) block copolymers (PEG-
b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited strong Q band absorption around 650 nm, a useful wavelength for high tissue penetration. Dynamic light scattering studies indicated that the DPcZn/m system has a relevant size of 50 nm for intravenous administration. Under light irradiation, either DPcZn or DPcZn/m exhibited efficient consumption of dissolved oxygen in a medium to generate reactive oxygen species and an irradiation-time-dependent increase in photocytotoxicity. The photodynamic efficacy of the DPcZn was drastically improved by the incorporation into the polymeric micelles, typically exhibiting more than two orders of magnitude higher photocytotoxicity compared with the free DPcZn at 60-min photoirradiation. |
| doi_str_mv | 10.1016/j.jconrel.2006.03.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19437485</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168365906001131</els_id><sourcerecordid>19437485</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-59fc208975dafdd2eb265d872aebf0da02cee7ad9d6e0b220615aab656b095223</originalsourceid><addsrcrecordid>eNqFkc9u1DAQxiMEotvCI4B8gVvC5I-TmAtCFZRKleAAZ8uxJ12vHDvY3qXhlXhJHDZSj5ys8fy--UbzZdmrEooSyvbdoThIZz2aogJoC6gLAPYk25V9V-cNY_Rptktcn9ctZRfZZQgHAKB10z3PLsq2g5KVdJf9-ebMop0l0k2zwQcyaYnGYCCj82Teu-jUYkX6JXGPXszLe3JrpfOz8yKuQjcShVZ5HRPzTxDQhlT9Rk_wQeooBoNERGKcvSe_xAkN2vu4J2l5PAkbSXRET7N3J1Qk6hCOmM9oMa4OSZI6M_q4vMiejcIEfLm9V9mPz5--X3_J777e3F5_vMtlwyDmlI2ygp51VIlRqQqHqqWq7yqBwwhKQCURO6GYahGGqoK2pEIMLW0HYLSq6qvs7XluMv55xBD5pMN6FWHRHQMvWVN3TU8TSM-g9C4EjyOfvZ6EX3gJfE2JH_iWEl9T4lDzlFLSvd4MjsOE6lG1xZKANxsgghRm9MJKHR65ru8YNG3iPpw5TOc4afQ8SI1WotIeZeTK6f-s8heYS7pr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19437485</pqid></control><display><type>article</type><title>Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Jang, Woo-Dong ; Nakagishi, Yoshinori ; Nishiyama, Nobuhiro ; Kawauchi, Satoko ; Morimoto, Yuji ; Kikuchi, Makoto ; Kataoka, Kazunori</creator><creatorcontrib>Jang, Woo-Dong ; Nakagishi, Yoshinori ; Nishiyama, Nobuhiro ; Kawauchi, Satoko ; Morimoto, Yuji ; Kikuchi, Makoto ; Kataoka, Kazunori</creatorcontrib><description>A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly(
l-lysine) block copolymers (PEG-
b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited strong Q band absorption around 650 nm, a useful wavelength for high tissue penetration. Dynamic light scattering studies indicated that the DPcZn/m system has a relevant size of 50 nm for intravenous administration. Under light irradiation, either DPcZn or DPcZn/m exhibited efficient consumption of dissolved oxygen in a medium to generate reactive oxygen species and an irradiation-time-dependent increase in photocytotoxicity. The photodynamic efficacy of the DPcZn was drastically improved by the incorporation into the polymeric micelles, typically exhibiting more than two orders of magnitude higher photocytotoxicity compared with the free DPcZn at 60-min photoirradiation.</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2006.03.009</identifier><identifier>PMID: 16701915</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Biological and medical sciences ; Cell Culture Techniques ; Cell Survival - radiation effects ; Dendrimer ; Dendrimers - chemical synthesis ; Dendrimers - chemistry ; Dendrimers - metabolism ; Dendrimers - radiation effects ; Dendrimers - toxicity ; Dose-Response Relationship, Drug ; General pharmacology ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Indoles - chemical synthesis ; Indoles - chemistry ; Indoles - metabolism ; Indoles - radiation effects ; Indoles - toxicity ; Light ; Medical sciences ; Micelles ; Oxygen Consumption ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Photochemotherapy ; Photodynamic therapy ; Photosensitizer ; Phthalocyanine ; Polyamines ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - toxicity ; Polylysine - chemistry ; Polylysine - toxicity ; Polymeric micelle ; Polymers ; Reactive Oxygen Species - metabolism ; Solubility ; Static Electricity ; Water - chemistry</subject><ispartof>Journal of controlled release, 2006-06, Vol.113 (1), p.73-79</ispartof><rights>2006 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-59fc208975dafdd2eb265d872aebf0da02cee7ad9d6e0b220615aab656b095223</citedby><cites>FETCH-LOGICAL-c490t-59fc208975dafdd2eb265d872aebf0da02cee7ad9d6e0b220615aab656b095223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2006.03.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17879046$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16701915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Woo-Dong</creatorcontrib><creatorcontrib>Nakagishi, Yoshinori</creatorcontrib><creatorcontrib>Nishiyama, Nobuhiro</creatorcontrib><creatorcontrib>Kawauchi, Satoko</creatorcontrib><creatorcontrib>Morimoto, Yuji</creatorcontrib><creatorcontrib>Kikuchi, Makoto</creatorcontrib><creatorcontrib>Kataoka, Kazunori</creatorcontrib><title>Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly(
l-lysine) block copolymers (PEG-
b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited strong Q band absorption around 650 nm, a useful wavelength for high tissue penetration. Dynamic light scattering studies indicated that the DPcZn/m system has a relevant size of 50 nm for intravenous administration. Under light irradiation, either DPcZn or DPcZn/m exhibited efficient consumption of dissolved oxygen in a medium to generate reactive oxygen species and an irradiation-time-dependent increase in photocytotoxicity. The photodynamic efficacy of the DPcZn was drastically improved by the incorporation into the polymeric micelles, typically exhibiting more than two orders of magnitude higher photocytotoxicity compared with the free DPcZn at 60-min photoirradiation.</description><subject>Biological and medical sciences</subject><subject>Cell Culture Techniques</subject><subject>Cell Survival - radiation effects</subject><subject>Dendrimer</subject><subject>Dendrimers - chemical synthesis</subject><subject>Dendrimers - chemistry</subject><subject>Dendrimers - metabolism</subject><subject>Dendrimers - radiation effects</subject><subject>Dendrimers - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>General pharmacology</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Indoles - chemical synthesis</subject><subject>Indoles - chemistry</subject><subject>Indoles - metabolism</subject><subject>Indoles - radiation effects</subject><subject>Indoles - toxicity</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Micelles</subject><subject>Oxygen Consumption</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Photochemotherapy</subject><subject>Photodynamic therapy</subject><subject>Photosensitizer</subject><subject>Phthalocyanine</subject><subject>Polyamines</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - toxicity</subject><subject>Polylysine - chemistry</subject><subject>Polylysine - toxicity</subject><subject>Polymeric micelle</subject><subject>Polymers</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Solubility</subject><subject>Static Electricity</subject><subject>Water - chemistry</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiMEotvCI4B8gVvC5I-TmAtCFZRKleAAZ8uxJ12vHDvY3qXhlXhJHDZSj5ys8fy--UbzZdmrEooSyvbdoThIZz2aogJoC6gLAPYk25V9V-cNY_Rptktcn9ctZRfZZQgHAKB10z3PLsq2g5KVdJf9-ebMop0l0k2zwQcyaYnGYCCj82Teu-jUYkX6JXGPXszLe3JrpfOz8yKuQjcShVZ5HRPzTxDQhlT9Rk_wQeooBoNERGKcvSe_xAkN2vu4J2l5PAkbSXRET7N3J1Qk6hCOmM9oMa4OSZI6M_q4vMiejcIEfLm9V9mPz5--X3_J777e3F5_vMtlwyDmlI2ygp51VIlRqQqHqqWq7yqBwwhKQCURO6GYahGGqoK2pEIMLW0HYLSq6qvs7XluMv55xBD5pMN6FWHRHQMvWVN3TU8TSM-g9C4EjyOfvZ6EX3gJfE2JH_iWEl9T4lDzlFLSvd4MjsOE6lG1xZKANxsgghRm9MJKHR65ru8YNG3iPpw5TOc4afQ8SI1WotIeZeTK6f-s8heYS7pr</recordid><startdate>20060612</startdate><enddate>20060612</enddate><creator>Jang, Woo-Dong</creator><creator>Nakagishi, Yoshinori</creator><creator>Nishiyama, Nobuhiro</creator><creator>Kawauchi, Satoko</creator><creator>Morimoto, Yuji</creator><creator>Kikuchi, Makoto</creator><creator>Kataoka, Kazunori</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20060612</creationdate><title>Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property</title><author>Jang, Woo-Dong ; Nakagishi, Yoshinori ; Nishiyama, Nobuhiro ; Kawauchi, Satoko ; Morimoto, Yuji ; Kikuchi, Makoto ; Kataoka, Kazunori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-59fc208975dafdd2eb265d872aebf0da02cee7ad9d6e0b220615aab656b095223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Cell Culture Techniques</topic><topic>Cell Survival - radiation effects</topic><topic>Dendrimer</topic><topic>Dendrimers - chemical synthesis</topic><topic>Dendrimers - chemistry</topic><topic>Dendrimers - metabolism</topic><topic>Dendrimers - radiation effects</topic><topic>Dendrimers - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>General pharmacology</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Indoles - chemical synthesis</topic><topic>Indoles - chemistry</topic><topic>Indoles - metabolism</topic><topic>Indoles - radiation effects</topic><topic>Indoles - toxicity</topic><topic>Light</topic><topic>Medical sciences</topic><topic>Micelles</topic><topic>Oxygen Consumption</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Photochemotherapy</topic><topic>Photodynamic therapy</topic><topic>Photosensitizer</topic><topic>Phthalocyanine</topic><topic>Polyamines</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - toxicity</topic><topic>Polylysine - chemistry</topic><topic>Polylysine - toxicity</topic><topic>Polymeric micelle</topic><topic>Polymers</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Solubility</topic><topic>Static Electricity</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Woo-Dong</creatorcontrib><creatorcontrib>Nakagishi, Yoshinori</creatorcontrib><creatorcontrib>Nishiyama, Nobuhiro</creatorcontrib><creatorcontrib>Kawauchi, Satoko</creatorcontrib><creatorcontrib>Morimoto, Yuji</creatorcontrib><creatorcontrib>Kikuchi, Makoto</creatorcontrib><creatorcontrib>Kataoka, Kazunori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Woo-Dong</au><au>Nakagishi, Yoshinori</au><au>Nishiyama, Nobuhiro</au><au>Kawauchi, Satoko</au><au>Morimoto, Yuji</au><au>Kikuchi, Makoto</au><au>Kataoka, Kazunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2006-06-12</date><risdate>2006</risdate><volume>113</volume><issue>1</issue><spage>73</spage><epage>79</epage><pages>73-79</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly(
l-lysine) block copolymers (PEG-
b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited strong Q band absorption around 650 nm, a useful wavelength for high tissue penetration. Dynamic light scattering studies indicated that the DPcZn/m system has a relevant size of 50 nm for intravenous administration. Under light irradiation, either DPcZn or DPcZn/m exhibited efficient consumption of dissolved oxygen in a medium to generate reactive oxygen species and an irradiation-time-dependent increase in photocytotoxicity. The photodynamic efficacy of the DPcZn was drastically improved by the incorporation into the polymeric micelles, typically exhibiting more than two orders of magnitude higher photocytotoxicity compared with the free DPcZn at 60-min photoirradiation.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16701915</pmid><doi>10.1016/j.jconrel.2006.03.009</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2006-06, Vol.113 (1), p.73-79 |
| issn | 0168-3659 1873-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_19437485 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Cell Culture Techniques Cell Survival - radiation effects Dendrimer Dendrimers - chemical synthesis Dendrimers - chemistry Dendrimers - metabolism Dendrimers - radiation effects Dendrimers - toxicity Dose-Response Relationship, Drug General pharmacology HeLa Cells Humans Hydrogen-Ion Concentration Indoles - chemical synthesis Indoles - chemistry Indoles - metabolism Indoles - radiation effects Indoles - toxicity Light Medical sciences Micelles Oxygen Consumption Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Photochemotherapy Photodynamic therapy Photosensitizer Phthalocyanine Polyamines Polyethylene Glycols - chemistry Polyethylene Glycols - toxicity Polylysine - chemistry Polylysine - toxicity Polymeric micelle Polymers Reactive Oxygen Species - metabolism Solubility Static Electricity Water - chemistry |
| title | Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T13%3A05%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polyion%20complex%20micelles%20for%20photodynamic%20therapy:%20Incorporation%20of%20dendritic%20photosensitizer%20excitable%20at%20long%20wavelength%20relevant%20to%20improved%20tissue-penetrating%20property&rft.jtitle=Journal%20of%20controlled%20release&rft.au=Jang,%20Woo-Dong&rft.date=2006-06-12&rft.volume=113&rft.issue=1&rft.spage=73&rft.epage=79&rft.pages=73-79&rft.issn=0168-3659&rft.eissn=1873-4995&rft.coden=JCREEC&rft_id=info:doi/10.1016/j.jconrel.2006.03.009&rft_dat=%3Cproquest_cross%3E19437485%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19437485&rft_id=info:pmid/16701915&rft_els_id=S0168365906001131&rfr_iscdi=true |