{alpha}-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models

Alpha-synuclein ({alpha}Syn) misfolding is associated with several devastating neurodegenerative disorders, including Parkinson's disease (PD). In yeast cells and in neurons {alpha}Syn accumulation is cytotoxic, but little is known about its normal function or pathobiology. The earliest defect...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2006-07, Vol.313 (5785), p.324-328
Hauptverfasser:	Cooper, Antony A, Gitler, Aaron D, Cashikar, Anil, Haynes, Cole M, Hill, Kathryn J, Bhullar, Bhupinder, Liu, Kangning, Xu, Kexiang, Strathearn, Katherine E, Liu, Fang, Cao, Songsong, Caldwell, Kim A, Caldwell, Guy A, Marsischky, Gerald, Kolodner, Richard D, LaBaer, Joshua, Rochet, Jean-Christophe, Bonini, Nancy M, Lindquist, Susan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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