Triptorelin Tethered Multifunctional PAMAM-Histidine-PEG Nanoconstructs Enable Specific Targeting and Efficient Gene Silencing in LHRH Overexpressing Cancer Cells

Cancer treatment using siRNA based therapies pose various limitations such as off-target effects and degradation due to lack of specific delivery in desired cells. The aim of the present study was to develop multifunctional targeted nanoconstructs, which can efficiently and precisely deliver siRNA a...

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Veröffentlicht in:	ACS applied materials & interfaces 2017-10, Vol.9 (41), p.35562-35573
Hauptverfasser:	Tambe, Prajakta, Kumar, Pramod, Karpe, Yogesh A, Paknikar, Kishore M, Gajbhiye, Virendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Gene Silencing Histidine Humans Male Nanoparticles RNA, Small Interfering Triptorelin Pamoate
Online-Zugang:	Volltext
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