The compound (3-{5-[(2,5-dimethoxyphenyl)amino]-1,3,4-thiadiazolidin-2-yl}-5,8-methoxy-2H-chromen-2-one) inhibits the prion protein conversion from PrPC to PrPSc with lower IC50 in ScN2a cells

[Display omitted] Prion diseases are fatal neurodegenerative disorders of the central nervous system characterized by the accumulation of a protease resistant form (PrPSc) of the cellular prion protein (PrPC) in the brain. Two types of cellular prion (PrPC) compounds have been identified that appear...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2017-10, Vol.25 (20), p.5875-5888
Hauptverfasser:	Pagadala, Nataraj S., Bjorndahl, Trent C., Joyce, Michael, Wishart, David S., Syed, Khajamohiddin, Landi, Abdolamir
Format:	Artikel
Sprache:	eng
Schlagworte:	CoMFA Docking HQSAR NMR Prion ScN2a cells
Online-Zugang:	Volltext
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