Dose-Related Safety and Immunogenicity of a Trivalent Baculovirus-Expressed Influenza-Virus Hemagglutinin Vaccine in Elderly Adults

BackgroundInfluenza-virus hemagglutinin (HA) protein expressed in insect cells by recombinant baculovirus is a candidate influenza vaccine MethodsIn a randomized, double-blind trial conducted in 399 adults ⩾65 years of age, the efficacy of trivalent inactivated influenza vaccine (TIV) licensed for i...

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Veröffentlicht in:	The Journal of infectious diseases 2006-05, Vol.193 (9), p.1223-1228
Hauptverfasser:	Treanor, John J., Schiff, Gilbert M., Couch, Robert B., Cate, Thomas R., Brady, Rebecca C., Hay, C. Mhorag, Wolff, Mark, She, Dewei, Cox, Manon M. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies Antibodies, Viral - blood Baculoviridae Baculoviridae - genetics Baculovirus Dosage Dose response relationship Dose-Response Relationship, Immunologic Female H3N2 subtype influenza A virus Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans Immune response Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Male Maximum Tolerated Dose Middle Aged Older adults Vaccination Vaccines, Inactivated - adverse effects Vaccines, Inactivated - genetics Vaccines, Inactivated - immunology Viruses
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Zusammenfassung:	BackgroundInfluenza-virus hemagglutinin (HA) protein expressed in insect cells by recombinant baculovirus is a candidate influenza vaccine MethodsIn a randomized, double-blind trial conducted in 399 adults ⩾65 years of age, the efficacy of trivalent inactivated influenza vaccine (TIV) licensed for intramuscular injection was compared with that of trivalent baculovirus-expressed HA vaccine administered at doses of 15 μg, 45 μg, or 135 μg of each HA ResultsCompared with TIV, baculovirus-expressed HA vaccine was safe and induced better serum antibody responses to the H3 component when administered at doses of 45 μg or 135 μg of each HA ConclusionsBaculovirus-expressed HA is a safe and immunogenic influenza vaccine in elderly adults
ISSN:	0022-1899 1537-6613
DOI:	10.1086/503050