Application of a blood–brain-barrier-penetrating form of GDNF in a mouse model for Parkinson's disease

Glial-cell-line-derived neurotrophic factor (GDNF) promotes mesencephalic dopaminergic neuronal survival in several in vitro and in vivo models. As the demise of dopaminergic neurons is the cause for Parkinson's disease (PD) symptoms, GDNF is a promising agent for its treatment. However, this n...

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Veröffentlicht in:	Brain research 2006-04, Vol.1082 (1), p.61-66
Hauptverfasser:	Dietz, Gunnar P.H., Valbuena, Paola C., Dietz, Birgit, Meuer, Katrin, Müller, Patrick, Weishaupt, Jochen H., Bähr, Mathias
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage Animals Biological and medical sciences Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiopathology Blood–brain barrier Cell Count - methods Cell-penetrating peptide (CPP) Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Drug Interactions Fundamental and applied biological sciences. Psychology Gene Products, tat - therapeutic use Gene Transfer Techniques Genes, tat Genetic Vectors Glial Cell Line-Derived Neurotrophic Factor - therapeutic use Human immunodeficiency virus Immunohistochemistry - methods Lentivirus Medical sciences Mice MPTP mouse model Neurology Neuroprotection Neuroprotective Agents - therapeutic use Parkinson Disease - drug therapy Parkinson Disease - etiology Peptides - pharmacology Protein transduction domain (PTD) Substantia Nigra - drug effects Substantia Nigra - metabolism Substantia Nigra - pathology Tyrosine 3-Monooxygenase - metabolism Vertebrates: nervous system and sense organs
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