Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

Previous studies show increased levels of lipid peroxidation and neurotoxic by-products of lipid peroxidation including 4-hydroxynonenal (HNE) and acrolein in vulnerable regions of the Alzheimer's disease (AD) brain. To determine if lipid peroxidation occurs early in progression of AD, we analy...

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Veröffentlicht in:	Neurobiology of aging 2006-08, Vol.27 (8), p.1094-1099
Hauptverfasser:	Williams, Taufika Islam, Lynn, Bert C., Markesbery, William R., Lovell, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - metabolism Aged, 80 and over Aldehydes - metabolism Alzheimer Disease - metabolism Alzheimer's disease Biomarkers - metabolism Brain - metabolism Cognition Disorders - metabolism Early Alzheimer's disease Female Humans Lipid Peroxidation Male Mild Cognitive Impairment Oxidative stress Tissue Distribution
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