Design and synthesis of new triazoles linked to xanthotoxin for potent and highly selective anti-gastric cancer agents

Two novel series of xanthotoxin-triazole derivatives were designed, synthesized, characterized and evaluated for their antiproliferative activity. [Display omitted] •Two novel series of xanthotoxin-triazole were designed and synthesized.•Compound 6p was found to have the better antiproliferative act...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2017-11, Vol.27 (21), p.4871-4875
Hauptverfasser:	Shen, Qing-Kun, Liu, Chuan-Feng, Zhang, Hong-Jian, Tian, Yu-Shun, Quan, Zhe-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	AGS cells Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Antiproliferation Apoptosis - drug effects Cell Line Cell Proliferation - drug effects Drug Design G2 Phase Cell Cycle Checkpoints - drug effects Humans Methoxsalen - chemical synthesis Methoxsalen - chemistry Methoxsalen - toxicity S Phase Cell Cycle Checkpoints - drug effects Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Structure-Activity Relationship Triazole Triazoles - chemistry Xanthotoxin
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