MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads
MECAT combines fast alignment with error correction and de novo assembly for the processing of long single-molecule reads derived from large genomes. We present a tool that combines fast mapping, error correction, and de novo assembly (MECAT; accessible at https://github.com/xiaochuanle/MECAT ) for...
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| Veröffentlicht in: | Nature methods 2017-11, Vol.14 (11), p.1072-1074 |
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| container_title | Nature methods |
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| creator | Xiao, Chuan-Le Chen, Ying Xie, Shang-Qian Chen, Kai-Ning Wang, Yan Han, Yue Luo, Feng Xie, Zhi |
| description | MECAT combines fast alignment with error correction and
de novo
assembly for the processing of long single-molecule reads derived from large genomes.
We present a tool that combines fast mapping, error correction, and
de novo
assembly (MECAT; accessible at
https://github.com/xiaochuanle/MECAT
) for processing single-molecule sequencing (SMS) reads. MECAT's computing efficiency is superior to that of current tools, while the results MECAT produces are comparable or improved. MECAT enables reference mapping or
de novo
assembly of large genomes using SMS reads on a single computer. |
| doi_str_mv | 10.1038/nmeth.4432 |
| format | Article |
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de novo
assembly for the processing of long single-molecule reads derived from large genomes.
We present a tool that combines fast mapping, error correction, and
de novo
assembly (MECAT; accessible at
https://github.com/xiaochuanle/MECAT
) for processing single-molecule sequencing (SMS) reads. MECAT's computing efficiency is superior to that of current tools, while the results MECAT produces are comparable or improved. MECAT enables reference mapping or
de novo
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de novo
assembly for the processing of long single-molecule reads derived from large genomes.
We present a tool that combines fast mapping, error correction, and
de novo
assembly (MECAT; accessible at
https://github.com/xiaochuanle/MECAT
) for processing single-molecule sequencing (SMS) reads. MECAT's computing efficiency is superior to that of current tools, while the results MECAT produces are comparable or improved. MECAT enables reference mapping or
de novo
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Academic</collection><jtitle>Nature methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Chuan-Le</au><au>Chen, Ying</au><au>Xie, Shang-Qian</au><au>Chen, Kai-Ning</au><au>Wang, Yan</au><au>Han, Yue</au><au>Luo, Feng</au><au>Xie, Zhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads</atitle><jtitle>Nature methods</jtitle><stitle>Nat Methods</stitle><addtitle>Nat Methods</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>14</volume><issue>11</issue><spage>1072</spage><epage>1074</epage><pages>1072-1074</pages><issn>1548-7091</issn><eissn>1548-7105</eissn><abstract>MECAT combines fast alignment with error correction and
de novo
assembly for the processing of long single-molecule reads derived from large genomes.
We present a tool that combines fast mapping, error correction, and
de novo
assembly (MECAT; accessible at
https://github.com/xiaochuanle/MECAT
) for processing single-molecule sequencing (SMS) reads. MECAT's computing efficiency is superior to that of current tools, while the results MECAT produces are comparable or improved. MECAT enables reference mapping or
de novo
assembly of large genomes using SMS reads on a single computer.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28945707</pmid><doi>10.1038/nmeth.4432</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-8821-2344</orcidid><orcidid>https://orcid.org/0000-0002-5589-4836</orcidid><orcidid>https://orcid.org/0000-0002-4680-0682</orcidid><orcidid>https://orcid.org/0000-0002-4813-2403</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 45/23 631/114/2397 631/114/2785 631/1647/514/1948 Algorithms Assembly Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology brief-communication Computing time Error correction Error correction & detection Escherichia coli Gene mapping Genomes High-Throughput Nucleotide Sequencing - methods Invertebrates Life Sciences Mapping Proteomics Sequence Analysis, DNA - methods Software |
| title | MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads |
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