MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads

MECAT combines fast alignment with error correction and de novo assembly for the processing of long single-molecule reads derived from large genomes. We present a tool that combines fast mapping, error correction, and de novo assembly (MECAT; accessible at https://github.com/xiaochuanle/MECAT ) for processing single-molecule sequencing (SMS) reads. MECAT's computing efficiency is superior to that of current tools, while the results MECAT produces are comparable or improved. MECAT enables reference mapping or de novo assembly of large genomes using SMS reads on a single computer.