Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets

•It is the first time to simultaneous determination the pharmacokinetics of CuB and CuE in rat plasma after oral administration of cucurbitacin tablets, which have been used to treatment of chronic hepatitis.•A simplicity and sensitivity UHPLC-MS/MS method was developed and validated.•A better separ...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2017-10, Vol.1065-1066, p.63-69
Hauptverfasser:	Wang, Zhibin, Zhu, Wenbo, Gao, Mingjie, Wu, Chengcui, Yang, Chunjuan, Yang, Jing, Wu, Gaosong, Yang, Bingyou, Kuang, Haixue
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Chromatography, High Pressure Liquid - methods Cucurbitacin B Cucurbitacin e Cucurbitacins - administration & dosage Cucurbitacins - pharmacokinetics Linear Models Male Pharmacokinetics Plant Extracts Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Tablets Tandem Mass Spectrometry - methods Triterpenes - blood Triterpenes - chemistry Triterpenes - pharmacokinetics UHPLC-MS/MS
Online-Zugang:	Volltext
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