Early Administration of Adjuvant β‐Lactam Therapy in Combination with Vancomycin among Patients with Methicillin‐Resistant Staphylococcus aureus Bloodstream Infection: A Retrospective, Multicenter Analysis

Study Objective To determine whether early administration of adjuvant β‐lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with methicillin‐resistant Staphylococcus aureus (MRSA) bloodstream infection. Design Re...

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Veröffentlicht in:	Pharmacotherapy 2017-11, Vol.37 (11), p.1347-1356
Hauptverfasser:	Casapao, Anthony M., Jacobs, David M., Bowers, Dana R., Beyda, Nicholas D., Dilworth, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Aged Aged, 80 and over Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use bacteremia Bacteremia - drug therapy Bacteremia - microbiology beta-Lactams - administration & dosage beta-Lactams - therapeutic use Cohort Studies combination therapy Drug Therapy, Combination Female Humans Logistic Models Male Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - isolation & purification methicillin‐resistant Staphylococcus aureus Middle Aged Retrospective Studies Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Treatment Outcome vancomycin Vancomycin - administration & dosage Vancomycin - therapeutic use β‐lactam
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