Hormones Are Key Actors in Gene X Environment Interactions Programming the Vulnerability to Parkinson's Disease: Glia as a Common Final Pathway

Alterations in developmental programming of neuroendocrine and immune system function may critically modulate vulnerability to various diseases. In particular, genetic factors, including gender, may interact with early life events such as exposure to hormones, endotoxins, or neurotoxins, thereby inf...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2005-12, Vol.1057 (1), p.296-318
Hauptverfasser:	MARCHETTI, BIANCA, SERRA, PIER ANDREA, L'EPISCOPO, FRANCESCA, TIROLO, CATALDO, CANIGLIA, SALVO, TESTA, NUCCIO, CIONI, SERENA, GENNUSO, FLORINDA, ROCCHITTA, GAIA, DESOLE, MARIA SPERANZA, MAZZARINO, MARIA CLORINDA, MIELE, EGIDIO, MORALE, MARIA CONCETTA
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - metabolism Animals Brain - growth & development Brain - metabolism Brain - physiology Dopamine - metabolism dopaminergic neurons Environment Estrogens - metabolism genes Genetic Predisposition to Disease glia Glucocorticoids - metabolism hormones Hormones - metabolism Humans neurodegeneration Neuroglia - physiology neuroinflammation Neurons - physiology neuroprotection Neurotoxins - metabolism Nitric Oxide Synthase Type II - metabolism Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - physiopathology Parkinson's disease
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