Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract
Purpose To investigate the ultrastructure of the lens epithelial cells (LECs) in patients with idiopathic congenital cataract. Methods This is a prospective interventional study. The anterior lens capsules (aLC: basement membrane and associated LECs) were taken from 16 eyes of 12 consecutive patient...
Gespeichert in:
| Veröffentlicht in: | International ophthalmology 2018-10, Vol.38 (5), p.2127-2132 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2132 |
|---|---|
| container_issue | 5 |
| container_start_page | 2127 |
| container_title | International ophthalmology |
| container_volume | 38 |
| creator | Tekin, Kemal Erol, Yasemin Ozdamar Inanc, Merve Sargon, Mustafa Fevzi Can, Cigdem Ulku Polat, Sibel Yilmazbas, Pelin |
| description | Purpose
To investigate the ultrastructure of the lens epithelial cells (LECs) in patients with idiopathic congenital cataract.
Methods
This is a prospective interventional study. The anterior lens capsules (aLC: basement membrane and associated LECs) were taken from 16 eyes of 12 consecutive patients who were diagnosed as having idiopathic congenital cataracts. The aLCs were obtained from cataract surgery and prepared for transmission electron microscopy (TEM).
Results
Some significant ultrastructural changes were observed in all aLCs of the participants. The anterior LECs showed alterations in different areas which were partly cuboidal and partly squamous in shape. The LECs had euchromatic nucleus and included some vacuoles in the cytoplasms as a remarkable alteration. The sizes of these intraepithelial cell vacuoles were changeable.
Conclusions
We identified remarkable changes in LECs of the eyes with idiopathic congenital cataract by TEM. It can be assumed that oxidative damage may be associated with these ultrastructural changes in LECs of the eyes with idiopathic congenital cataracts. |
| doi_str_mv | 10.1007/s10792-017-0713-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1942737933</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2104078990</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-d3db5b8101dd9969504410c002bf73c0d1846b556772603d35efbc0993fcecd13</originalsourceid><addsrcrecordid>eNp1kU9vFSEUxYmxsa9_PoAbQ-LGzei9MAyPpWmqNWnixq4JA4ylzsAIjKbfXl5e1cTEFcnhx-Hecwh5ifAWAeS7giAV6wBlBxJ5h8_IDoXkHRs4PCc7wEF0QgKekrNSHgBASTW8IKdsr3omerkj365nb2tOkS7B5lRsWoOl_oeZN1NDk9NETaw-h5Tp7GOhfg313s9hW2iIdG2Uj7XQn02lwYXUlPtmYVP86mOoZqbWVJONrRfkZDJz8ZdP5zm5-3D95eqmu_388dPV-9vOcslq57gbxbhHQOeUGpSAvkewAGycJLfgcN8PoxCDlGwA7rjw02hBKT5Zbx3yc_Lm6Lvm9H3zpeolFOvn2USftqKxLS-5VJw39PU_6EPacmzTaYbQg9wrBY3CI3VIqGQ_6TWHxeRHjaAPTehjE7o1oQ9N6MMQr56ct3Hx7s-L39E3gB2B0q5aVvnv1_93_QXeZZR7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2104078990</pqid></control><display><type>article</type><title>Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract</title><source>SpringerNature Journals</source><creator>Tekin, Kemal ; Erol, Yasemin Ozdamar ; Inanc, Merve ; Sargon, Mustafa Fevzi ; Can, Cigdem Ulku ; Polat, Sibel ; Yilmazbas, Pelin</creator><creatorcontrib>Tekin, Kemal ; Erol, Yasemin Ozdamar ; Inanc, Merve ; Sargon, Mustafa Fevzi ; Can, Cigdem Ulku ; Polat, Sibel ; Yilmazbas, Pelin</creatorcontrib><description>Purpose
To investigate the ultrastructure of the lens epithelial cells (LECs) in patients with idiopathic congenital cataract.
Methods
This is a prospective interventional study. The anterior lens capsules (aLC: basement membrane and associated LECs) were taken from 16 eyes of 12 consecutive patients who were diagnosed as having idiopathic congenital cataracts. The aLCs were obtained from cataract surgery and prepared for transmission electron microscopy (TEM).
Results
Some significant ultrastructural changes were observed in all aLCs of the participants. The anterior LECs showed alterations in different areas which were partly cuboidal and partly squamous in shape. The LECs had euchromatic nucleus and included some vacuoles in the cytoplasms as a remarkable alteration. The sizes of these intraepithelial cell vacuoles were changeable.
Conclusions
We identified remarkable changes in LECs of the eyes with idiopathic congenital cataract by TEM. It can be assumed that oxidative damage may be associated with these ultrastructural changes in LECs of the eyes with idiopathic congenital cataracts.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-017-0713-1</identifier><identifier>PMID: 28942547</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Cataracts ; Congenital diseases ; Epithelium ; Lenses ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Paper ; Transmission electron microscopy</subject><ispartof>International ophthalmology, 2018-10, Vol.38 (5), p.2127-2132</ispartof><rights>Springer Science+Business Media B.V. 2017</rights><rights>International Ophthalmology is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-d3db5b8101dd9969504410c002bf73c0d1846b556772603d35efbc0993fcecd13</citedby><cites>FETCH-LOGICAL-c372t-d3db5b8101dd9969504410c002bf73c0d1846b556772603d35efbc0993fcecd13</cites><orcidid>0000-0002-7461-6129</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-017-0713-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-017-0713-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28942547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tekin, Kemal</creatorcontrib><creatorcontrib>Erol, Yasemin Ozdamar</creatorcontrib><creatorcontrib>Inanc, Merve</creatorcontrib><creatorcontrib>Sargon, Mustafa Fevzi</creatorcontrib><creatorcontrib>Can, Cigdem Ulku</creatorcontrib><creatorcontrib>Polat, Sibel</creatorcontrib><creatorcontrib>Yilmazbas, Pelin</creatorcontrib><title>Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To investigate the ultrastructure of the lens epithelial cells (LECs) in patients with idiopathic congenital cataract.
Methods
This is a prospective interventional study. The anterior lens capsules (aLC: basement membrane and associated LECs) were taken from 16 eyes of 12 consecutive patients who were diagnosed as having idiopathic congenital cataracts. The aLCs were obtained from cataract surgery and prepared for transmission electron microscopy (TEM).
Results
Some significant ultrastructural changes were observed in all aLCs of the participants. The anterior LECs showed alterations in different areas which were partly cuboidal and partly squamous in shape. The LECs had euchromatic nucleus and included some vacuoles in the cytoplasms as a remarkable alteration. The sizes of these intraepithelial cell vacuoles were changeable.
Conclusions
We identified remarkable changes in LECs of the eyes with idiopathic congenital cataract by TEM. It can be assumed that oxidative damage may be associated with these ultrastructural changes in LECs of the eyes with idiopathic congenital cataracts.</description><subject>Cataracts</subject><subject>Congenital diseases</subject><subject>Epithelium</subject><subject>Lenses</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Transmission electron microscopy</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU9vFSEUxYmxsa9_PoAbQ-LGzei9MAyPpWmqNWnixq4JA4ylzsAIjKbfXl5e1cTEFcnhx-Hecwh5ifAWAeS7giAV6wBlBxJ5h8_IDoXkHRs4PCc7wEF0QgKekrNSHgBASTW8IKdsr3omerkj365nb2tOkS7B5lRsWoOl_oeZN1NDk9NETaw-h5Tp7GOhfg313s9hW2iIdG2Uj7XQn02lwYXUlPtmYVP86mOoZqbWVJONrRfkZDJz8ZdP5zm5-3D95eqmu_388dPV-9vOcslq57gbxbhHQOeUGpSAvkewAGycJLfgcN8PoxCDlGwA7rjw02hBKT5Zbx3yc_Lm6Lvm9H3zpeolFOvn2USftqKxLS-5VJw39PU_6EPacmzTaYbQg9wrBY3CI3VIqGQ_6TWHxeRHjaAPTehjE7o1oQ9N6MMQr56ct3Hx7s-L39E3gB2B0q5aVvnv1_93_QXeZZR7</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Tekin, Kemal</creator><creator>Erol, Yasemin Ozdamar</creator><creator>Inanc, Merve</creator><creator>Sargon, Mustafa Fevzi</creator><creator>Can, Cigdem Ulku</creator><creator>Polat, Sibel</creator><creator>Yilmazbas, Pelin</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7461-6129</orcidid></search><sort><creationdate>20181001</creationdate><title>Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract</title><author>Tekin, Kemal ; Erol, Yasemin Ozdamar ; Inanc, Merve ; Sargon, Mustafa Fevzi ; Can, Cigdem Ulku ; Polat, Sibel ; Yilmazbas, Pelin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-d3db5b8101dd9969504410c002bf73c0d1846b556772603d35efbc0993fcecd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cataracts</topic><topic>Congenital diseases</topic><topic>Epithelium</topic><topic>Lenses</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Transmission electron microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tekin, Kemal</creatorcontrib><creatorcontrib>Erol, Yasemin Ozdamar</creatorcontrib><creatorcontrib>Inanc, Merve</creatorcontrib><creatorcontrib>Sargon, Mustafa Fevzi</creatorcontrib><creatorcontrib>Can, Cigdem Ulku</creatorcontrib><creatorcontrib>Polat, Sibel</creatorcontrib><creatorcontrib>Yilmazbas, Pelin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tekin, Kemal</au><au>Erol, Yasemin Ozdamar</au><au>Inanc, Merve</au><au>Sargon, Mustafa Fevzi</au><au>Can, Cigdem Ulku</au><au>Polat, Sibel</au><au>Yilmazbas, Pelin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>38</volume><issue>5</issue><spage>2127</spage><epage>2132</epage><pages>2127-2132</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To investigate the ultrastructure of the lens epithelial cells (LECs) in patients with idiopathic congenital cataract.
Methods
This is a prospective interventional study. The anterior lens capsules (aLC: basement membrane and associated LECs) were taken from 16 eyes of 12 consecutive patients who were diagnosed as having idiopathic congenital cataracts. The aLCs were obtained from cataract surgery and prepared for transmission electron microscopy (TEM).
Results
Some significant ultrastructural changes were observed in all aLCs of the participants. The anterior LECs showed alterations in different areas which were partly cuboidal and partly squamous in shape. The LECs had euchromatic nucleus and included some vacuoles in the cytoplasms as a remarkable alteration. The sizes of these intraepithelial cell vacuoles were changeable.
Conclusions
We identified remarkable changes in LECs of the eyes with idiopathic congenital cataract by TEM. It can be assumed that oxidative damage may be associated with these ultrastructural changes in LECs of the eyes with idiopathic congenital cataracts.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>28942547</pmid><doi>10.1007/s10792-017-0713-1</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7461-6129</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5701 |
| ispartof | International ophthalmology, 2018-10, Vol.38 (5), p.2127-2132 |
| issn | 0165-5701 1573-2630 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1942737933 |
| source | SpringerNature Journals |
| subjects | Cataracts Congenital diseases Epithelium Lenses Medicine Medicine & Public Health Ophthalmology Original Paper Transmission electron microscopy |
| title | Electron microscopic evaluation of anterior lens epithelium in patients with idiopathic congenital cataract |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T15%3A45%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Electron%20microscopic%20evaluation%20of%20anterior%20lens%20epithelium%20in%20patients%20with%20idiopathic%20congenital%20cataract&rft.jtitle=International%20ophthalmology&rft.au=Tekin,%20Kemal&rft.date=2018-10-01&rft.volume=38&rft.issue=5&rft.spage=2127&rft.epage=2132&rft.pages=2127-2132&rft.issn=0165-5701&rft.eissn=1573-2630&rft_id=info:doi/10.1007/s10792-017-0713-1&rft_dat=%3Cproquest_cross%3E2104078990%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2104078990&rft_id=info:pmid/28942547&rfr_iscdi=true |