MicroRNA-21 promotes osteogenesis of bone marrow mesenchymal stem cells via the Smad7-Smad1/5/8-Runx2 pathway

Bone marrow mesenchymal stem cells (BMMSCs) are pluripotent stem cells, and the osteogenic differentiation of BMMSCs has been drawing attention for a long time. Bone formation is regulated by numerous molecular and cellular signaling pathways, and the differentiation of BMMSCs is controlled by a wel...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-11, Vol.493 (2), p.928-933
Hauptverfasser:	Li, Xiaoyan, Guo, Lijia, Liu, Yitong, Su, Yingying, Xie, Yongmei, Du, Juan, Zhou, Jian, Ding, Gang, Wang, Hao, Bai, Yuxing, Liu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BMMSCs Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Differentiation Cells, Cultured Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Differentiation Female Gene Expression Regulation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice, Inbred C57BL Mice, Knockout MicroRNAs - genetics MicroRNAs - metabolism miR-21 Osteogenesis Signal Transduction Smad Proteins - genetics Smad Proteins - metabolism
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