Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam
Sedation with fentanyl and midazolam during bronchoscopic examination is commonly employed by pulmonary physicians in the USA and Europe. We assessed the efficacy of such sedation in the bronchoscopic diagnosis of peripheral lung cancer. We retrospectively evaluated data from 102 patients who underw...
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| Veröffentlicht in: | Respiratory investigation 2017-09, Vol.55 (5), p.314-317 |
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| creator | Minami, Daisuke Nakasuka, Takamasa Ando, Chihiro Iwamoto, MD, Yoshitaka Sato, Ken Fujiwara, Keiichi Shibayama, Takuo Yonei, MD, PhD, Toshirou Sato, Toshio |
| description | Sedation with fentanyl and midazolam during bronchoscopic examination is commonly employed by pulmonary physicians in the USA and Europe. We assessed the efficacy of such sedation in the bronchoscopic diagnosis of peripheral lung cancer.
We retrospectively evaluated data from 102 patients who underwent transbronchial biopsies (TBB) for diagnosis of peripheral lung cancer. Bronchoscopies with and without fentanyl were performed in 61 (group A) and 41 (group B) patients, respectively. Midazolam was administered to all patients. Medical records were retrieved, and between-group comparisons were made using unpaired Student's t-tests.
The mean fentanyl dose was 49.5 μg (range: 10–100 μg), and midazolam doses in groups A and B were 4.29mg (range: 1–14mg) and 5.54mg (range: 1–12mg), respectively. Diagnostic histological specimens were obtained from 75.4% and 65.8% of group A and B patients, respectively (P = 0.30). The diagnostic sensitivities for lung cancer, via at least one of TBB, cytological brushing, or bronchial washing, in groups A and B were 88.5% and 70.4%, respectively (P = 0.035). Moreover, lesion diagnostic sensitivities, via at least one of TBB, cytological brushing, and bronchial washing, in groups A and B were 98.1% and 68.0%, respectively (P = 0.01).
Fentanyl and midazolam sedation during bronchoscopy facilitated the diagnosis of peripheral pulmonary lung cancers. |
| doi_str_mv | 10.1016/j.resinv.2017.07.001 |
| format | Article |
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We retrospectively evaluated data from 102 patients who underwent transbronchial biopsies (TBB) for diagnosis of peripheral lung cancer. Bronchoscopies with and without fentanyl were performed in 61 (group A) and 41 (group B) patients, respectively. Midazolam was administered to all patients. Medical records were retrieved, and between-group comparisons were made using unpaired Student's t-tests.
The mean fentanyl dose was 49.5 μg (range: 10–100 μg), and midazolam doses in groups A and B were 4.29mg (range: 1–14mg) and 5.54mg (range: 1–12mg), respectively. Diagnostic histological specimens were obtained from 75.4% and 65.8% of group A and B patients, respectively (P = 0.30). The diagnostic sensitivities for lung cancer, via at least one of TBB, cytological brushing, or bronchial washing, in groups A and B were 88.5% and 70.4%, respectively (P = 0.035). Moreover, lesion diagnostic sensitivities, via at least one of TBB, cytological brushing, and bronchial washing, in groups A and B were 98.1% and 68.0%, respectively (P = 0.01).
Fentanyl and midazolam sedation during bronchoscopy facilitated the diagnosis of peripheral pulmonary lung cancers.</description><identifier>ISSN: 2212-5345</identifier><identifier>EISSN: 2212-5353</identifier><identifier>DOI: 10.1016/j.resinv.2017.07.001</identifier><identifier>PMID: 28942887</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Aged ; Aged, 80 and over ; Biopsy - methods ; Bronchoscopy ; Bronchoscopy - methods ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - pathology ; Conscious Sedation - methods ; Female ; Fentanyl ; Fentanyl - administration & dosage ; Humans ; Hypnotics and Sedatives - administration & dosage ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - pathology ; Male ; Midazolam ; Midazolam - administration & dosage ; Middle Aged ; Retrospective Studies ; Sedation ; Sensitivity and Specificity ; Small Cell Lung Carcinoma - diagnosis ; Small Cell Lung Carcinoma - pathology</subject><ispartof>Respiratory investigation, 2017-09, Vol.55 (5), p.314-317</ispartof><rights>2017 The Japanese Respiratory Society</rights><rights>Copyright © 2017 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-acebd2858fdae1ecb9f2b2387b314f7093d829d2b2f7741289b2aae78cf43fa43</citedby><cites>FETCH-LOGICAL-c386t-acebd2858fdae1ecb9f2b2387b314f7093d829d2b2f7741289b2aae78cf43fa43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28942887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minami, Daisuke</creatorcontrib><creatorcontrib>Nakasuka, Takamasa</creatorcontrib><creatorcontrib>Ando, Chihiro</creatorcontrib><creatorcontrib>Iwamoto, MD, Yoshitaka</creatorcontrib><creatorcontrib>Sato, Ken</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Shibayama, Takuo</creatorcontrib><creatorcontrib>Yonei, MD, PhD, Toshirou</creatorcontrib><creatorcontrib>Sato, Toshio</creatorcontrib><title>Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam</title><title>Respiratory investigation</title><addtitle>Respir Investig</addtitle><description>Sedation with fentanyl and midazolam during bronchoscopic examination is commonly employed by pulmonary physicians in the USA and Europe. We assessed the efficacy of such sedation in the bronchoscopic diagnosis of peripheral lung cancer.
We retrospectively evaluated data from 102 patients who underwent transbronchial biopsies (TBB) for diagnosis of peripheral lung cancer. Bronchoscopies with and without fentanyl were performed in 61 (group A) and 41 (group B) patients, respectively. Midazolam was administered to all patients. Medical records were retrieved, and between-group comparisons were made using unpaired Student's t-tests.
The mean fentanyl dose was 49.5 μg (range: 10–100 μg), and midazolam doses in groups A and B were 4.29mg (range: 1–14mg) and 5.54mg (range: 1–12mg), respectively. Diagnostic histological specimens were obtained from 75.4% and 65.8% of group A and B patients, respectively (P = 0.30). The diagnostic sensitivities for lung cancer, via at least one of TBB, cytological brushing, or bronchial washing, in groups A and B were 88.5% and 70.4%, respectively (P = 0.035). Moreover, lesion diagnostic sensitivities, via at least one of TBB, cytological brushing, and bronchial washing, in groups A and B were 98.1% and 68.0%, respectively (P = 0.01).
Fentanyl and midazolam sedation during bronchoscopy facilitated the diagnosis of peripheral pulmonary lung cancers.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy - methods</subject><subject>Bronchoscopy</subject><subject>Bronchoscopy - methods</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Conscious Sedation - methods</subject><subject>Female</subject><subject>Fentanyl</subject><subject>Fentanyl - administration & dosage</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - administration & dosage</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Midazolam</subject><subject>Midazolam - administration & dosage</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Sedation</subject><subject>Sensitivity and Specificity</subject><subject>Small Cell Lung Carcinoma - diagnosis</subject><subject>Small Cell Lung Carcinoma - pathology</subject><issn>2212-5345</issn><issn>2212-5353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LBDEMhosoKuo_EOnRy65tZ2bbuQgqfoHgRc-l06Zul047tjPK-uvtsurREEgIbxLeB6FTSuaU0MXFap4gu_AxZ4TyOSlJ6A46ZIyyWVM11e5fXzcH6CTnFSmxaFhNF_vogIm2ZkLwQ7S6TjHoZcw6Dk5j49RbiNllHC0eILlhCUl5PEy-j0GlNfZTeMNaBQ0JQz_4uHZlkMGo0cWAP924xBbCqMLaYxUM7p1RX9Gr_hjtWeUznPzUI_R6d_ty8zB7er5_vLl6mulKLMaZ0tAZJhphjQIKumst61gleFfR2nLSVkaw1pSZ5bymxUrHlAIutK0rq-rqCJ1v7w4pvk-QR9m7rMF7FSBOWdLinRPB24203kp1ijknsHJIri82JSVyA1qu5Ba03ICWpCShZe3s58PU9WD-ln6xFsHlVgDF54eDJLN2UJgZl0CP0kT3_4dvobKT4A</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Minami, Daisuke</creator><creator>Nakasuka, Takamasa</creator><creator>Ando, Chihiro</creator><creator>Iwamoto, MD, Yoshitaka</creator><creator>Sato, Ken</creator><creator>Fujiwara, Keiichi</creator><creator>Shibayama, Takuo</creator><creator>Yonei, MD, PhD, Toshirou</creator><creator>Sato, Toshio</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam</title><author>Minami, Daisuke ; Nakasuka, Takamasa ; Ando, Chihiro ; Iwamoto, MD, Yoshitaka ; Sato, Ken ; Fujiwara, Keiichi ; Shibayama, Takuo ; Yonei, MD, PhD, Toshirou ; Sato, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-acebd2858fdae1ecb9f2b2387b314f7093d829d2b2f7741289b2aae78cf43fa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy - methods</topic><topic>Bronchoscopy</topic><topic>Bronchoscopy - methods</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Conscious Sedation - methods</topic><topic>Female</topic><topic>Fentanyl</topic><topic>Fentanyl - administration & dosage</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - administration & dosage</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Midazolam</topic><topic>Midazolam - administration & dosage</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Sedation</topic><topic>Sensitivity and Specificity</topic><topic>Small Cell Lung Carcinoma - diagnosis</topic><topic>Small Cell Lung Carcinoma - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minami, Daisuke</creatorcontrib><creatorcontrib>Nakasuka, Takamasa</creatorcontrib><creatorcontrib>Ando, Chihiro</creatorcontrib><creatorcontrib>Iwamoto, MD, Yoshitaka</creatorcontrib><creatorcontrib>Sato, Ken</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Shibayama, Takuo</creatorcontrib><creatorcontrib>Yonei, MD, PhD, Toshirou</creatorcontrib><creatorcontrib>Sato, Toshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minami, Daisuke</au><au>Nakasuka, Takamasa</au><au>Ando, Chihiro</au><au>Iwamoto, MD, Yoshitaka</au><au>Sato, Ken</au><au>Fujiwara, Keiichi</au><au>Shibayama, Takuo</au><au>Yonei, MD, PhD, Toshirou</au><au>Sato, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam</atitle><jtitle>Respiratory investigation</jtitle><addtitle>Respir Investig</addtitle><date>2017-09</date><risdate>2017</risdate><volume>55</volume><issue>5</issue><spage>314</spage><epage>317</epage><pages>314-317</pages><issn>2212-5345</issn><eissn>2212-5353</eissn><abstract>Sedation with fentanyl and midazolam during bronchoscopic examination is commonly employed by pulmonary physicians in the USA and Europe. We assessed the efficacy of such sedation in the bronchoscopic diagnosis of peripheral lung cancer.
We retrospectively evaluated data from 102 patients who underwent transbronchial biopsies (TBB) for diagnosis of peripheral lung cancer. Bronchoscopies with and without fentanyl were performed in 61 (group A) and 41 (group B) patients, respectively. Midazolam was administered to all patients. Medical records were retrieved, and between-group comparisons were made using unpaired Student's t-tests.
The mean fentanyl dose was 49.5 μg (range: 10–100 μg), and midazolam doses in groups A and B were 4.29mg (range: 1–14mg) and 5.54mg (range: 1–12mg), respectively. Diagnostic histological specimens were obtained from 75.4% and 65.8% of group A and B patients, respectively (P = 0.30). The diagnostic sensitivities for lung cancer, via at least one of TBB, cytological brushing, or bronchial washing, in groups A and B were 88.5% and 70.4%, respectively (P = 0.035). Moreover, lesion diagnostic sensitivities, via at least one of TBB, cytological brushing, and bronchial washing, in groups A and B were 98.1% and 68.0%, respectively (P = 0.01).
Fentanyl and midazolam sedation during bronchoscopy facilitated the diagnosis of peripheral pulmonary lung cancers.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28942887</pmid><doi>10.1016/j.resinv.2017.07.001</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - pathology Aged Aged, 80 and over Biopsy - methods Bronchoscopy Bronchoscopy - methods Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Conscious Sedation - methods Female Fentanyl Fentanyl - administration & dosage Humans Hypnotics and Sedatives - administration & dosage Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - pathology Male Midazolam Midazolam - administration & dosage Middle Aged Retrospective Studies Sedation Sensitivity and Specificity Small Cell Lung Carcinoma - diagnosis Small Cell Lung Carcinoma - pathology |
| title | Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam |
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