Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease
The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited. A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory...
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| Veröffentlicht in: | International journal of cardiology 2017-12, Vol.248, p.173-178 |
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| container_title | International journal of cardiology |
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| creator | Nortamo, Santeri Ukkola, Olavi Lepojärvi, Samuli Kenttä, Tuomas Kiviniemi, Antti Junttila, Juhani Huikuri, Heikki Perkiömäki, Juha |
| description | The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited.
A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis.
During 5.7±1.5years of follow-up, 143 (8.4%) patients developed a new-onset AF. Higher values of soluble ST2 (sST2) (20.2±10.8 vs. 17.5±7.2ng/mL, p=0.005), high-sensitivity troponin T (hs-TnT) (11.9±10.2 vs. 10.3±8.3ng/L, p=0.005), high-sensitivity C-reactive protein (hs-CRP) (3.3±5.9 vs. 2.0±4.4mg/L, p |
| doi_str_mv | 10.1016/j.ijcard.2017.07.022 |
| format | Article |
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A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis.
During 5.7±1.5years of follow-up, 143 (8.4%) patients developed a new-onset AF. Higher values of soluble ST2 (sST2) (20.2±10.8 vs. 17.5±7.2ng/mL, p=0.005), high-sensitivity troponin T (hs-TnT) (11.9±10.2 vs. 10.3±8.3ng/L, p=0.005), high-sensitivity C-reactive protein (hs-CRP) (3.3±5.9 vs. 2.0±4.4mg/L, p<0.001) and brain natriuretic peptide (BNP) (85.6±77.5 vs. 64.9±73.5ng/L, p<0.001) had significant associations with the occurrence of new-onset AF. In the Cox clinical hazards model, higher age (p=0.004), greater weight (p=0.045), larger left atrial diameter (p=0.001), use of asthma/chronic obstructive pulmonary disease medication (p=0.001) and lack of cholesterol lowering medication (p=0.008) had a significant association with the increased risk of AF. When the biomarkers were tested in the Cox clinical hazards model, sST2 (HR=1.025, 95% CI=1.007–1.043, p=0.006) and hs-CRP (HR=1.027, 95% CI=1.008–1.047, p=0.006) retained their significant power in predicting AF.
A biomarker of fibrosis, sST2, and a biomarker of inflammation, hs-CRP, predict the risk of occurrence of new-onset AF in patients with CAD. These biomarkers contributed to the discrimination of the AF risk model, but did not improve it markedly.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2017.07.022</identifier><identifier>PMID: 28942872</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Atrial fibrillation ; Atrial fibrosis ; Brain natriuretic peptide ; Cardiac biomarkers ; Inflammatory markers</subject><ispartof>International journal of cardiology, 2017-12, Vol.248, p.173-178</ispartof><rights>2017 Elsevier Ireland Ltd</rights><rights>Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-dd791b42ec8fef239c7cd140c3d7aa66a7588d2a25355b320e8f9fc3530b36e03</citedby><cites>FETCH-LOGICAL-c388t-dd791b42ec8fef239c7cd140c3d7aa66a7588d2a25355b320e8f9fc3530b36e03</cites><orcidid>0000-0002-1160-493X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167527317323112$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28942872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nortamo, Santeri</creatorcontrib><creatorcontrib>Ukkola, Olavi</creatorcontrib><creatorcontrib>Lepojärvi, Samuli</creatorcontrib><creatorcontrib>Kenttä, Tuomas</creatorcontrib><creatorcontrib>Kiviniemi, Antti</creatorcontrib><creatorcontrib>Junttila, Juhani</creatorcontrib><creatorcontrib>Huikuri, Heikki</creatorcontrib><creatorcontrib>Perkiömäki, Juha</creatorcontrib><title>Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited.
A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis.
During 5.7±1.5years of follow-up, 143 (8.4%) patients developed a new-onset AF. Higher values of soluble ST2 (sST2) (20.2±10.8 vs. 17.5±7.2ng/mL, p=0.005), high-sensitivity troponin T (hs-TnT) (11.9±10.2 vs. 10.3±8.3ng/L, p=0.005), high-sensitivity C-reactive protein (hs-CRP) (3.3±5.9 vs. 2.0±4.4mg/L, p<0.001) and brain natriuretic peptide (BNP) (85.6±77.5 vs. 64.9±73.5ng/L, p<0.001) had significant associations with the occurrence of new-onset AF. In the Cox clinical hazards model, higher age (p=0.004), greater weight (p=0.045), larger left atrial diameter (p=0.001), use of asthma/chronic obstructive pulmonary disease medication (p=0.001) and lack of cholesterol lowering medication (p=0.008) had a significant association with the increased risk of AF. When the biomarkers were tested in the Cox clinical hazards model, sST2 (HR=1.025, 95% CI=1.007–1.043, p=0.006) and hs-CRP (HR=1.027, 95% CI=1.008–1.047, p=0.006) retained their significant power in predicting AF.
A biomarker of fibrosis, sST2, and a biomarker of inflammation, hs-CRP, predict the risk of occurrence of new-onset AF in patients with CAD. These biomarkers contributed to the discrimination of the AF risk model, but did not improve it markedly.</description><subject>Atrial fibrillation</subject><subject>Atrial fibrosis</subject><subject>Brain natriuretic peptide</subject><subject>Cardiac biomarkers</subject><subject>Inflammatory markers</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMoOl7eQCRLNx1zaZt0I8jgDQTFyzqkySlm6DSa01F8eyMdXQoHzub7z-Uj5JizOWe8PlvOw9LZ5OeCcTVnuYTYIjOuVVlwVZXbZJYxVVRCyT2yj7hkjJVNo3fJntBNKbQSM-IuEKMLdgxxoLGj-PQsqB08fcVi8fhAe_iAHulnGF_pAJ9FHBBGascUbE-70KbQ91M4DNTFFAebvqhNI-TmA4JFOCQ7ne0Rjjb9gLxcXT4vboq7--vbxcVd4aTWY-G9anhbCnC6g07Ixinnecmc9Mrauraq0toLKypZVa0UDHTXdE5WkrWyBiYPyOk09y3F9zXgaFYBHeQDB4hrNDw_rZhWtcxoOaEuRcQEnXlLYZVPN5yZH71maSa95kevYbmEyLGTzYZ1uwL_F_r1mYHzCcjS4CNAMugCDA58SOBG42P4f8M3niWN7w</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Nortamo, Santeri</creator><creator>Ukkola, Olavi</creator><creator>Lepojärvi, Samuli</creator><creator>Kenttä, Tuomas</creator><creator>Kiviniemi, Antti</creator><creator>Junttila, Juhani</creator><creator>Huikuri, Heikki</creator><creator>Perkiömäki, Juha</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1160-493X</orcidid></search><sort><creationdate>20171201</creationdate><title>Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease</title><author>Nortamo, Santeri ; Ukkola, Olavi ; Lepojärvi, Samuli ; Kenttä, Tuomas ; Kiviniemi, Antti ; Junttila, Juhani ; Huikuri, Heikki ; Perkiömäki, Juha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-dd791b42ec8fef239c7cd140c3d7aa66a7588d2a25355b320e8f9fc3530b36e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Atrial fibrillation</topic><topic>Atrial fibrosis</topic><topic>Brain natriuretic peptide</topic><topic>Cardiac biomarkers</topic><topic>Inflammatory markers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nortamo, Santeri</creatorcontrib><creatorcontrib>Ukkola, Olavi</creatorcontrib><creatorcontrib>Lepojärvi, Samuli</creatorcontrib><creatorcontrib>Kenttä, Tuomas</creatorcontrib><creatorcontrib>Kiviniemi, Antti</creatorcontrib><creatorcontrib>Junttila, Juhani</creatorcontrib><creatorcontrib>Huikuri, Heikki</creatorcontrib><creatorcontrib>Perkiömäki, Juha</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nortamo, Santeri</au><au>Ukkola, Olavi</au><au>Lepojärvi, Samuli</au><au>Kenttä, Tuomas</au><au>Kiviniemi, Antti</au><au>Junttila, Juhani</au><au>Huikuri, Heikki</au><au>Perkiömäki, Juha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>248</volume><spage>173</spage><epage>178</epage><pages>173-178</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited.
A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis.
During 5.7±1.5years of follow-up, 143 (8.4%) patients developed a new-onset AF. Higher values of soluble ST2 (sST2) (20.2±10.8 vs. 17.5±7.2ng/mL, p=0.005), high-sensitivity troponin T (hs-TnT) (11.9±10.2 vs. 10.3±8.3ng/L, p=0.005), high-sensitivity C-reactive protein (hs-CRP) (3.3±5.9 vs. 2.0±4.4mg/L, p<0.001) and brain natriuretic peptide (BNP) (85.6±77.5 vs. 64.9±73.5ng/L, p<0.001) had significant associations with the occurrence of new-onset AF. In the Cox clinical hazards model, higher age (p=0.004), greater weight (p=0.045), larger left atrial diameter (p=0.001), use of asthma/chronic obstructive pulmonary disease medication (p=0.001) and lack of cholesterol lowering medication (p=0.008) had a significant association with the increased risk of AF. When the biomarkers were tested in the Cox clinical hazards model, sST2 (HR=1.025, 95% CI=1.007–1.043, p=0.006) and hs-CRP (HR=1.027, 95% CI=1.008–1.047, p=0.006) retained their significant power in predicting AF.
A biomarker of fibrosis, sST2, and a biomarker of inflammation, hs-CRP, predict the risk of occurrence of new-onset AF in patients with CAD. These biomarkers contributed to the discrimination of the AF risk model, but did not improve it markedly.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28942872</pmid><doi>10.1016/j.ijcard.2017.07.022</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-1160-493X</orcidid></addata></record> |
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| subjects | Atrial fibrillation Atrial fibrosis Brain natriuretic peptide Cardiac biomarkers Inflammatory markers |
| title | Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease |
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