Cellular Mechanics of Primary Human Cervical Fibroblasts: Influence of Progesterone and a Pro-inflammatory Cytokine

The leading cause of neonatal mortality, pre-term birth, is often caused by pre-mature ripening/opening of the uterine cervix. Although cervical fibroblasts play an important role in modulating the cervix’s extracellular matrix (ECM) and mechanical properties, it is not known how hormones, i.e., pro...

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Veröffentlicht in:	Annals of biomedical engineering 2018, Vol.46 (1), p.197-207
Hauptverfasser:	Shukla, Vasudha, Barnhouse, Victoria, Ackerman, William E., Summerfield, Taryn L., Powell, Heather M., Leight, Jennifer L., Kniss, Douglas A., Ghadiali, Samir N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Biochemistry Biological and Medical Physics Biomechanics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Cell Adhesion - drug effects Cells, Cultured Cervix Cervix Uteri - cytology Classical Mechanics Collagen Collagen - metabolism Contractility Contraction Cytokines Estradiol - pharmacology Estrogens Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - physiology Female Fibroblasts Fibroblasts - drug effects Fibroblasts - physiology Gene expression Hormones Humans IL-1β Infant mortality Inflammation Interleukin-1beta - pharmacology Matrix Metalloproteinases - metabolism Mechanical properties Mechanics Neonates Pregnancy Premature birth Pretreatment Progesterone Progesterone - pharmacology Ripening Traction Traction force Uterus
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