Naturally occurring anthocyanin cyanidin-3-rutinoside possesses inherent vasorelaxant actions and prevents methylglyoxal-induced vascular dysfunction in rat aorta and mesenteric arterial bed

•Low concentrations of C3R promote endothelium-dependent vasodilation.•Intravenous administration of C3R induces hypotension in anesthetized rat.•Pre-treatment with MG enhances vascular contractility and impairs vasodilation.•C3R restores vascular functions (contraction/relaxation) in MG-treated ves...

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