Cognitive Trajectory Changes Over 20 Years Before Dementia Diagnosis: A Large Cohort Study

Background/Objectives Longitudinal studies have shown an increase in cognitive decline many years before clinical diagnosis of dementia. We sought to estimate changes, relative to “normal” aging, in the trajectory of scores on a global cognitive function test—the Cognitive Abilities Screening Instru...

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Veröffentlicht in:	Journal of the American Geriatrics Society (JAGS) 2017-12, Vol.65 (12), p.2627-2633
Hauptverfasser:	Li, Ge, Larson, Eric B., Shofer, Jane B., Crane, Paul K., Gibbons, Laura E., McCormick, Wayne, Bowen, James D., Thompson, Mary Lou
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Apolipoprotein E Apolipoproteins E - genetics change point Cognition Cognitive ability Cognitive Dysfunction - complications Cognitive Dysfunction - diagnosis Cognitive Dysfunction - genetics cognitive function Cohort analysis Dementia Dementia - diagnosis Dementia - genetics Dementia disorders Diagnosis Disease Progression Female Genotype Health maintenance organizations Health risk assessment HMOs Humans Item response theory Male Medical diagnosis Prospective Studies Sex Time Factors trajectory changes
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