Trypanosoma cruzi: Inhibition of infection of human monocytes by aspirin

Cell invasion by Trypanosoma cruzi and its intracellular replication are essential for progression of the parasite life cycle and development of Chagas disease. Prostaglandin E2 (PGE2) and other eicosanoids potently modulate host response and contribute to Chagas disease progression. In this study,...

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Veröffentlicht in:	Experimental parasitology 2017-11, Vol.182, p.26-33
Hauptverfasser:	Carvalho de Freitas, Rafael, Lonien, Sandra Cristina Heim, Malvezi, Aparecida Donizette, Silveira, Guilherme Ferreira, Wowk, Pryscilla Fanini, da Silva, Rosiane Valeriano, Yamauchi, Lucy Megumi, Yamada-Ogatta, Sueli Fumie, Rizzo, Luiz Vicente, Bordignon, Juliano, Pinge-Filho, Phileno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - chemistry Adenine - pharmacology Adenylate-cyclase Adenylyl Cyclase Inhibitors - chemistry Adenylyl Cyclase Inhibitors - pharmacology Adenylyl Cyclases - metabolism Adult Animals Aspirin Aspirin - pharmacology Cell invasion Cell Line Cell Survival Cyclic AMP - metabolism Cyclooxygenase Inhibitors - pharmacology Cytokines - metabolism Dinoprostone - metabolism Epithelial Cells - cytology Epithelial Cells - parasitology Humans Kidney - cytology Kidney - parasitology Macaca mulatta Monocytes - drug effects Monocytes - metabolism Monocytes - parasitology Nitric Oxide - metabolism Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - physiology
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