Edoxaban improves venous thrombosis via increasing hydrogen sulfide and homocysteine in rat model

Anticoagulant therapy is prescribed to millions of patients worldwide for the prevention and treatment of venous thrombosis. Evidence has indicated that edoxaban is a potential drug of oral anticoagulant in the acute treatment of venous thromboembolism. Hydrogen sulfide and homocysteine plasma conce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular medicine reports 2017-11, Vol.16 (5), p.7706-7714
Hauptverfasser:	Song, Wei, Ci, Hongbo, Tian, Guanglei, Zhang, Yanjun, Ge, Xiaohu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Anticoagulants Anticoagulants - pharmacology Blood platelets Cardiovascular diseases Chlorides - administration & dosage Cystathionine beta-Synthase - genetics Cystathionine beta-Synthase - metabolism Cystathionine gamma-Lyase - genetics Cystathionine gamma-Lyase - metabolism Disease Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule edoxaban Embolisms Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Enzymes Ferric Compounds - administration & dosage Gelatinase B Gene expression Gene Expression Regulation - drug effects Health risk assessment Homeostasis Homocysteine Homocysteine - agonists Homocysteine - blood Hydrogen Hydrogen sulfide Hydrogen Sulfide - agonists Hydrogen Sulfide - blood Kinases Laboratory animals Male Matrix metalloproteinase Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Metalloproteinase Microvasculature Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism phosphoinositide 3-kinase/protein kinase B Primary Cell Culture Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Pyridines - pharmacology Rats Rats, Sprague-Dawley Risk factors Signal Transduction Studies Sulfides Thiazoles - pharmacology Thromboembolism Thrombosis Veins & arteries venous thrombosis Venous Thrombosis - chemically induced Venous Thrombosis - drug therapy Venous Thrombosis - metabolism Venous Thrombosis - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!