Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model

Functional and structural damages to mitochondria have been critically associated with the pathogenesis of Down syndrome (DS), a human multifactorial disease caused by trisomy of chromosome 21 and associated with neurodevelopmental delay, intellectual disability and early neurodegeneration. Recently...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2017-12, Vol.1863 (12), p.3117-3127
Hauptverfasser:	Valenti, Daniela, Rossi, Leonardo, Marzulli, Domenico, Bellomo, Francesco, De Rasmo, Domenico, Signorile, Anna, Vacca, Rosa Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Disease Models, Animal Down syndrome Down Syndrome - metabolism Down Syndrome - pathology Drp1 Dynamins - antagonists & inhibitors Dynamins - metabolism Energy Metabolism GTP Phosphohydrolases - metabolism Hippocampal neurogenesis Hippocampus - metabolism Hippocampus - pathology Mdivi-1 Mice Mitochondria - metabolism Mitochondrial Dynamics - physiology Mitochondrial dysfunction Mitochondrial network Neurogenesis - physiology Optic Atrophy, Autosomal Dominant - metabolism Quinazolinones - antagonists & inhibitors Quinazolinones - metabolism
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