Simplified Method for Local Correction of System International Normalized Ratio

Simplified Method for Local Correction of System International Normalized Ratio

Abstract Background International normalized ratio (INR) derivation is dependent on the international sensitivity index (ISI) of thromboplastin. It varies with instrument and reagents used. Objective To evaluate the role of a correction factor in the derivation of INR. Methods We studied prothrombin...

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Veröffentlicht in:Laboratory medicine 2017-08, Vol.48 (3), p.244-248
1. Verfasser: Chandrashekar, Vani
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Sprache:eng
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Female
Humans
International Normalized Ratio - standards
Linear Models
Male
Middle Aged
Prothrombin Time - standards
Thromboplastin
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description Abstract Background International normalized ratio (INR) derivation is dependent on the international sensitivity index (ISI) of thromboplastin. It varies with instrument and reagents used. Objective To evaluate the role of a correction factor in the derivation of INR. Methods We studied prothrombin time (PT) and INR from patients using 3 thromboplastins of varying ISI values. The correction factor was applied to the observed INR to obtain a corrected INR. Results The difference between corrected INR and observed INR values varies from −0.8 through 0.96. Conclusions Corrected INR is dependent on PT only. It can be applied to all patients irrespective of cause for elevated PT.
doi_str_mv 10.1093/labmed/lmx028
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It varies with instrument and reagents used. Objective To evaluate the role of a correction factor in the derivation of INR. Methods We studied prothrombin time (PT) and INR from patients using 3 thromboplastins of varying ISI values. The correction factor was applied to the observed INR to obtain a corrected INR. Results The difference between corrected INR and observed INR values varies from −0.8 through 0.96. Conclusions Corrected INR is dependent on PT only. It can be applied to all patients irrespective of cause for elevated PT.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1093/labmed/lmx028</identifier><identifier>PMID: 28934513</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Female ; Humans ; International Normalized Ratio - standards ; Linear Models ; Male ; Middle Aged ; Prothrombin Time - standards ; Thromboplastin</subject><ispartof>Laboratory medicine, 2017-08, Vol.48 (3), p.244-248</ispartof><rights>American Society for Clinical Pathology, 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2017</rights><rights>American Society for Clinical Pathology, 2017. All rights reserved. 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It varies with instrument and reagents used. Objective To evaluate the role of a correction factor in the derivation of INR. Methods We studied prothrombin time (PT) and INR from patients using 3 thromboplastins of varying ISI values. The correction factor was applied to the observed INR to obtain a corrected INR. Results The difference between corrected INR and observed INR values varies from −0.8 through 0.96. Conclusions Corrected INR is dependent on PT only. 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subjects Female
Humans
International Normalized Ratio - standards
Linear Models
Male
Middle Aged
Prothrombin Time - standards
Thromboplastin
title Simplified Method for Local Correction of System International Normalized Ratio
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