Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines
The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopoly...
Gespeichert in:
| Veröffentlicht in: | Methods in enzymology 2017, Vol.597, p.335-357 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 357 |
|---|---|
| container_issue | |
| container_start_page | 335 |
| container_title | Methods in enzymology |
| container_volume | 597 |
| creator | Lakshminarayanan, Abirami Vijayakrishnan, Balakumar Bayley, Hagan Davis, Benjamin G |
| description | The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopolysaccharides in Gram-negative bacteria. However, due to the buried nature of such internal epitopes, this approach has been rarely adopted. Here we briefly review and compare strategic approaches and outline practical methods associated with evaluating one synergistic strategy that combines (i) blocking of the display of "external glycans" with (ii) vaccination targeted at "internal glycans." |
| doi_str_mv | 10.1016/bs.mie.2017.06.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1942676750</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1942676750</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-ea9ab986ed6c732b09e489f9dc4ba0c9612b727bbcf37ba0b51ddec75e8f2f783</originalsourceid><addsrcrecordid>eNo1j01LAzEURYMgtlb_gAsJXbmZMS_TycdSam0LBRe1bock86ZGZtI6SRfz7y1YVxfOPVy4hDwAy4GBeLYx7zzmnIHMmcgZU1dkDGUpM6mVGpHbGL8Z41JpuCEjrnRRArAxWW1TbxLuPUbqA01fSF8x-n2gJtR0F5EeGrodwrlI3tHpOiTsg2npsh2cCVP6aZzzAeMduW5MG_H-khOye1t8zFfZ5n25nr9ssiMHSBkabaxWAmvhZMEt0zhTutG1m1nDnBbAreTSWtcU8kxsCXWNTpaoGt5IVUzI09_usT_8nDCmqvPRYduagIdTrEDPuJBCluysPl7Uk-2wro6970w_VP_vi19AiFsl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1942676750</pqid></control><display><type>article</type><title>Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Lakshminarayanan, Abirami ; Vijayakrishnan, Balakumar ; Bayley, Hagan ; Davis, Benjamin G</creator><creatorcontrib>Lakshminarayanan, Abirami ; Vijayakrishnan, Balakumar ; Bayley, Hagan ; Davis, Benjamin G</creatorcontrib><description>The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopolysaccharides in Gram-negative bacteria. However, due to the buried nature of such internal epitopes, this approach has been rarely adopted. Here we briefly review and compare strategic approaches and outline practical methods associated with evaluating one synergistic strategy that combines (i) blocking of the display of "external glycans" with (ii) vaccination targeted at "internal glycans."</description><identifier>EISSN: 1557-7988</identifier><identifier>DOI: 10.1016/bs.mie.2017.06.008</identifier><identifier>PMID: 28935110</identifier><language>eng</language><publisher>United States</publisher><subject>Cell Wall - immunology ; Epitopes - chemistry ; Epitopes - immunology ; Glycoconjugates - chemistry ; Glycoconjugates - immunology ; Glycoconjugates - therapeutic use ; Gram-Negative Bacteria - immunology ; Gram-Negative Bacteria - pathogenicity ; Humans ; Lipopolysaccharides - chemistry ; Lipopolysaccharides - immunology ; Lipopolysaccharides - therapeutic use ; Polysaccharides - chemistry ; Polysaccharides - immunology ; Polysaccharides - therapeutic use ; Vaccines - biosynthesis ; Vaccines - chemistry ; Vaccines - immunology ; Vaccines - therapeutic use</subject><ispartof>Methods in enzymology, 2017, Vol.597, p.335-357</ispartof><rights>2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28935110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lakshminarayanan, Abirami</creatorcontrib><creatorcontrib>Vijayakrishnan, Balakumar</creatorcontrib><creatorcontrib>Bayley, Hagan</creatorcontrib><creatorcontrib>Davis, Benjamin G</creatorcontrib><title>Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines</title><title>Methods in enzymology</title><addtitle>Methods Enzymol</addtitle><description>The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopolysaccharides in Gram-negative bacteria. However, due to the buried nature of such internal epitopes, this approach has been rarely adopted. Here we briefly review and compare strategic approaches and outline practical methods associated with evaluating one synergistic strategy that combines (i) blocking of the display of "external glycans" with (ii) vaccination targeted at "internal glycans."</description><subject>Cell Wall - immunology</subject><subject>Epitopes - chemistry</subject><subject>Epitopes - immunology</subject><subject>Glycoconjugates - chemistry</subject><subject>Glycoconjugates - immunology</subject><subject>Glycoconjugates - therapeutic use</subject><subject>Gram-Negative Bacteria - immunology</subject><subject>Gram-Negative Bacteria - pathogenicity</subject><subject>Humans</subject><subject>Lipopolysaccharides - chemistry</subject><subject>Lipopolysaccharides - immunology</subject><subject>Lipopolysaccharides - therapeutic use</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - immunology</subject><subject>Polysaccharides - therapeutic use</subject><subject>Vaccines - biosynthesis</subject><subject>Vaccines - chemistry</subject><subject>Vaccines - immunology</subject><subject>Vaccines - therapeutic use</subject><issn>1557-7988</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j01LAzEURYMgtlb_gAsJXbmZMS_TycdSam0LBRe1bock86ZGZtI6SRfz7y1YVxfOPVy4hDwAy4GBeLYx7zzmnIHMmcgZU1dkDGUpM6mVGpHbGL8Z41JpuCEjrnRRArAxWW1TbxLuPUbqA01fSF8x-n2gJtR0F5EeGrodwrlI3tHpOiTsg2npsh2cCVP6aZzzAeMduW5MG_H-khOye1t8zFfZ5n25nr9ssiMHSBkabaxWAmvhZMEt0zhTutG1m1nDnBbAreTSWtcU8kxsCXWNTpaoGt5IVUzI09_usT_8nDCmqvPRYduagIdTrEDPuJBCluysPl7Uk-2wro6970w_VP_vi19AiFsl</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Lakshminarayanan, Abirami</creator><creator>Vijayakrishnan, Balakumar</creator><creator>Bayley, Hagan</creator><creator>Davis, Benjamin G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines</title><author>Lakshminarayanan, Abirami ; Vijayakrishnan, Balakumar ; Bayley, Hagan ; Davis, Benjamin G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-ea9ab986ed6c732b09e489f9dc4ba0c9612b727bbcf37ba0b51ddec75e8f2f783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cell Wall - immunology</topic><topic>Epitopes - chemistry</topic><topic>Epitopes - immunology</topic><topic>Glycoconjugates - chemistry</topic><topic>Glycoconjugates - immunology</topic><topic>Glycoconjugates - therapeutic use</topic><topic>Gram-Negative Bacteria - immunology</topic><topic>Gram-Negative Bacteria - pathogenicity</topic><topic>Humans</topic><topic>Lipopolysaccharides - chemistry</topic><topic>Lipopolysaccharides - immunology</topic><topic>Lipopolysaccharides - therapeutic use</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - immunology</topic><topic>Polysaccharides - therapeutic use</topic><topic>Vaccines - biosynthesis</topic><topic>Vaccines - chemistry</topic><topic>Vaccines - immunology</topic><topic>Vaccines - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lakshminarayanan, Abirami</creatorcontrib><creatorcontrib>Vijayakrishnan, Balakumar</creatorcontrib><creatorcontrib>Bayley, Hagan</creatorcontrib><creatorcontrib>Davis, Benjamin G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Methods in enzymology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakshminarayanan, Abirami</au><au>Vijayakrishnan, Balakumar</au><au>Bayley, Hagan</au><au>Davis, Benjamin G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines</atitle><jtitle>Methods in enzymology</jtitle><addtitle>Methods Enzymol</addtitle><date>2017</date><risdate>2017</risdate><volume>597</volume><spage>335</spage><epage>357</epage><pages>335-357</pages><eissn>1557-7988</eissn><abstract>The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopolysaccharides in Gram-negative bacteria. However, due to the buried nature of such internal epitopes, this approach has been rarely adopted. Here we briefly review and compare strategic approaches and outline practical methods associated with evaluating one synergistic strategy that combines (i) blocking of the display of "external glycans" with (ii) vaccination targeted at "internal glycans."</abstract><cop>United States</cop><pmid>28935110</pmid><doi>10.1016/bs.mie.2017.06.008</doi><tpages>23</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1557-7988 |
| ispartof | Methods in enzymology, 2017, Vol.597, p.335-357 |
| issn | 1557-7988 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1942676750 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cell Wall - immunology Epitopes - chemistry Epitopes - immunology Glycoconjugates - chemistry Glycoconjugates - immunology Glycoconjugates - therapeutic use Gram-Negative Bacteria - immunology Gram-Negative Bacteria - pathogenicity Humans Lipopolysaccharides - chemistry Lipopolysaccharides - immunology Lipopolysaccharides - therapeutic use Polysaccharides - chemistry Polysaccharides - immunology Polysaccharides - therapeutic use Vaccines - biosynthesis Vaccines - chemistry Vaccines - immunology Vaccines - therapeutic use |
| title | Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T11%3A45%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Strategies%20in%20the%20Design%20and%20Use%20of%20Synthetic%20%22Internal%20Glycan%22%20Vaccines&rft.jtitle=Methods%20in%20enzymology&rft.au=Lakshminarayanan,%20Abirami&rft.date=2017&rft.volume=597&rft.spage=335&rft.epage=357&rft.pages=335-357&rft.eissn=1557-7988&rft_id=info:doi/10.1016/bs.mie.2017.06.008&rft_dat=%3Cproquest_pubme%3E1942676750%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1942676750&rft_id=info:pmid/28935110&rfr_iscdi=true |