HDAC3 promotes meiotic apparatus assembly in mouse oocytes by modulating tubulin acetylation

Histone deacetylases (HDACs) have been shown to deacetylate numerous cellular substrates that govern a wide array of biological processes. HDAC3, a member of the Class I HDACs, is a highly conserved and ubiquitously expressed protein. However, its roles in meiotic oocytes are not known. In the prese...

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Veröffentlicht in:	Development (Cambridge) 2017-10, Vol.144 (20), p.3789-3797
Hauptverfasser:	Li, Xiaoyan, Liu, Xiaohui, Gao, Min, Han, Longsen, Qiu, Danhong, Wang, Haichao, Xiong, Bo, Sun, Shao-Chen, Liu, Honglin, Gu, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Aneuploidy Animals BUBR1 protein Cell Cycle Proteins - metabolism Chromosomes Deacetylation Female Histone Deacetylases - genetics Histone Deacetylases - metabolism Kinetochores Meiosis Metaphase Mice Mice, Inbred ICR Microtubules - metabolism Morphology Oocytes Oocytes - cytology Oocytes - metabolism Phenotype Protein-Serine-Threonine Kinases - metabolism Spindle Apparatus Tubulin Tubulin - metabolism
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