The pesticide malathion reduces survival and growth in developing zebrafish
Malathion is an organophosphorous pesticide widely used to control mosquitoes in urban areas and pests, such as boll weevils, in agricultural areas. Zebrafish, Danio rerio, are model organisms for developmental toxicology research because they are readily available, produce large numbers of clear em...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2005-07, Vol.24 (7), p.1745-1750 |
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| creator | Cook, Leslie W. Paradise, Christopher J. Lom, Barbara |
| description | Malathion is an organophosphorous pesticide widely used to control mosquitoes in urban areas and pests, such as boll weevils, in agricultural areas. Zebrafish, Danio rerio, are model organisms for developmental toxicology research because they are readily available, produce large numbers of clear embryos, and are sensitive to environmental changes. The nonlethal effects of malathion on developing zebrafish embryos, however, previously have not been analyzed quantitatively. We exposed zebrafish embryos to sublethal malathion concentrations to determine malathion's effects on a developing vertebrate. Zebrafish exposed to 0.5, 1.0, or 1.5 mg/L of malathion consistently elicited more rapid hatching from the chorion than zebrafish exposed to 2.0‐, 2.5‐, or 3.0‐mg/L malathion concentrations. In addition, exposure to 2.0, 2.5, or 3.0 mg/L of malathion resulted in significantly shorter body length and eye diameters, indicating that malathion had teratogenic effects on zebrafish embryos. Malathion's action as an acetylcholinesterase inhibitor and the toxicity of the metabolites of malathion may be responsible for malathion's teratogenic effects on fish development. |
| doi_str_mv | 10.1897/04-331R.1 |
| format | Article |
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Zebrafish, Danio rerio, are model organisms for developmental toxicology research because they are readily available, produce large numbers of clear embryos, and are sensitive to environmental changes. The nonlethal effects of malathion on developing zebrafish embryos, however, previously have not been analyzed quantitatively. We exposed zebrafish embryos to sublethal malathion concentrations to determine malathion's effects on a developing vertebrate. Zebrafish exposed to 0.5, 1.0, or 1.5 mg/L of malathion consistently elicited more rapid hatching from the chorion than zebrafish exposed to 2.0‐, 2.5‐, or 3.0‐mg/L malathion concentrations. In addition, exposure to 2.0, 2.5, or 3.0 mg/L of malathion resulted in significantly shorter body length and eye diameters, indicating that malathion had teratogenic effects on zebrafish embryos. Malathion's action as an acetylcholinesterase inhibitor and the toxicity of the metabolites of malathion may be responsible for malathion's teratogenic effects on fish development.</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1897/04-331R.1</identifier><identifier>PMID: 16050592</identifier><identifier>CODEN: ETOCDK</identifier><language>eng</language><publisher>Hoboken: Wiley Periodicals, Inc</publisher><subject>Agnatha. Pisces ; Animal reproduction ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Danio rerio ; Dose-Response Relationship, Drug ; Ecotoxicology, biological effects of pollution ; Embryogenesis ; Embryos ; Environmental changes ; Fish ; Freshwater ; Fundamental and applied biological sciences. Psychology ; General aspects ; Hatching ; Impact analysis ; Insecticides - toxicity ; Malathion ; Malathion - toxicity ; Metabolites ; Pesticide ; Pesticides ; Survival analysis ; Teratogens - toxicity ; Toxicology ; Urban areas ; Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution ; Water Pollutants, Chemical - toxicity ; Zebrafish ; Zebrafish - embryology</subject><ispartof>Environmental toxicology and chemistry, 2005-07, Vol.24 (7), p.1745-1750</ispartof><rights>Copyright © 2005 SETAC</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Allen Press, Inc. Jul 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5251-31dd7b7e168fad95b1a4dcb610fb470c807782aa6df7c7d3bf249449bef1ceca3</citedby><cites>FETCH-LOGICAL-c5251-31dd7b7e168fad95b1a4dcb610fb470c807782aa6df7c7d3bf249449bef1ceca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1897%2F04-331R.1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1897%2F04-331R.1$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16872553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16050592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cook, Leslie W.</creatorcontrib><creatorcontrib>Paradise, Christopher J.</creatorcontrib><creatorcontrib>Lom, Barbara</creatorcontrib><title>The pesticide malathion reduces survival and growth in developing zebrafish</title><title>Environmental toxicology and chemistry</title><addtitle>Environmental Toxicology and Chemistry</addtitle><description>Malathion is an organophosphorous pesticide widely used to control mosquitoes in urban areas and pests, such as boll weevils, in agricultural areas. Zebrafish, Danio rerio, are model organisms for developmental toxicology research because they are readily available, produce large numbers of clear embryos, and are sensitive to environmental changes. The nonlethal effects of malathion on developing zebrafish embryos, however, previously have not been analyzed quantitatively. We exposed zebrafish embryos to sublethal malathion concentrations to determine malathion's effects on a developing vertebrate. Zebrafish exposed to 0.5, 1.0, or 1.5 mg/L of malathion consistently elicited more rapid hatching from the chorion than zebrafish exposed to 2.0‐, 2.5‐, or 3.0‐mg/L malathion concentrations. In addition, exposure to 2.0, 2.5, or 3.0 mg/L of malathion resulted in significantly shorter body length and eye diameters, indicating that malathion had teratogenic effects on zebrafish embryos. Malathion's action as an acetylcholinesterase inhibitor and the toxicity of the metabolites of malathion may be responsible for malathion's teratogenic effects on fish development.</description><subject>Agnatha. Pisces</subject><subject>Animal reproduction</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Danio rerio</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Embryogenesis</subject><subject>Embryos</subject><subject>Environmental changes</subject><subject>Fish</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Hatching</subject><subject>Impact analysis</subject><subject>Insecticides - toxicity</subject><subject>Malathion</subject><subject>Malathion - toxicity</subject><subject>Metabolites</subject><subject>Pesticide</subject><subject>Pesticides</subject><subject>Survival analysis</subject><subject>Teratogens - toxicity</subject><subject>Toxicology</subject><subject>Urban areas</subject><subject>Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Zebrafish</subject><subject>Zebrafish - embryology</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0U1vEzEQBmALgWgoHPgDyEICicOW8eesj1UFARFAlCK4WV7b27hsdoOdTSm_no0SAUJCnObyzDseDyEPGZyw2uBzkJUQ7PyE3SIzphSvas3q22QGKKBCrusjcq-UKwCmjTF3yRHToEAZPiNvLpaRrmPZJJ9CpCvXuc0yDT3NMYw-FlrGvE1b11HXB3qZh-vNkqaehriN3bBO_SX9EZvs2lSW98md1nUlPjjUY_Lp5YuLs1fV4v389dnpovKKK1YJFgI2GJmuWxeMapiTwTeaQdtIBF8DYs2d06FFj0E0LZdGStPElvnonTgmT_e56zx8G6e321UqPnad6-MwFsuM5EIh_h9KnJKBT_DxX_BqGHM_LWE5A4GAEib0bI98HkrJsbXrnFYu31gGdncHC9Lu7mDZZB8dAsdmFcNvefj4CTw5AFe869rsep_KH65GrpSYnNy769TFm39PtBNSmgOXgHw3v9q3pbKJ33-1ufzVahSo7Od3c_th8eXj-dy8tVL8BNGGrdw</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Cook, Leslie W.</creator><creator>Paradise, Christopher J.</creator><creator>Lom, Barbara</creator><general>Wiley Periodicals, Inc</general><general>SETAC</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>SOI</scope><scope>7QH</scope><scope>7TV</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>200507</creationdate><title>The pesticide malathion reduces survival and growth in developing zebrafish</title><author>Cook, Leslie W. ; Paradise, Christopher J. ; Lom, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5251-31dd7b7e168fad95b1a4dcb610fb470c807782aa6df7c7d3bf249449bef1ceca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Agnatha. 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Psychology</topic><topic>General aspects</topic><topic>Hatching</topic><topic>Impact analysis</topic><topic>Insecticides - toxicity</topic><topic>Malathion</topic><topic>Malathion - toxicity</topic><topic>Metabolites</topic><topic>Pesticide</topic><topic>Pesticides</topic><topic>Survival analysis</topic><topic>Teratogens - toxicity</topic><topic>Toxicology</topic><topic>Urban areas</topic><topic>Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Zebrafish</topic><topic>Zebrafish - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cook, Leslie W.</creatorcontrib><creatorcontrib>Paradise, Christopher J.</creatorcontrib><creatorcontrib>Lom, Barbara</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cook, Leslie W.</au><au>Paradise, Christopher J.</au><au>Lom, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pesticide malathion reduces survival and growth in developing zebrafish</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environmental Toxicology and Chemistry</addtitle><date>2005-07</date><risdate>2005</risdate><volume>24</volume><issue>7</issue><spage>1745</spage><epage>1750</epage><pages>1745-1750</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><coden>ETOCDK</coden><abstract>Malathion is an organophosphorous pesticide widely used to control mosquitoes in urban areas and pests, such as boll weevils, in agricultural areas. Zebrafish, Danio rerio, are model organisms for developmental toxicology research because they are readily available, produce large numbers of clear embryos, and are sensitive to environmental changes. The nonlethal effects of malathion on developing zebrafish embryos, however, previously have not been analyzed quantitatively. We exposed zebrafish embryos to sublethal malathion concentrations to determine malathion's effects on a developing vertebrate. Zebrafish exposed to 0.5, 1.0, or 1.5 mg/L of malathion consistently elicited more rapid hatching from the chorion than zebrafish exposed to 2.0‐, 2.5‐, or 3.0‐mg/L malathion concentrations. In addition, exposure to 2.0, 2.5, or 3.0 mg/L of malathion resulted in significantly shorter body length and eye diameters, indicating that malathion had teratogenic effects on zebrafish embryos. Malathion's action as an acetylcholinesterase inhibitor and the toxicity of the metabolites of malathion may be responsible for malathion's teratogenic effects on fish development.</abstract><cop>Hoboken</cop><pub>Wiley Periodicals, Inc</pub><pmid>16050592</pmid><doi>10.1897/04-331R.1</doi><tpages>6</tpages></addata></record> |
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| subjects | Agnatha. Pisces Animal reproduction Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Danio rerio Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Embryogenesis Embryos Environmental changes Fish Freshwater Fundamental and applied biological sciences. Psychology General aspects Hatching Impact analysis Insecticides - toxicity Malathion Malathion - toxicity Metabolites Pesticide Pesticides Survival analysis Teratogens - toxicity Toxicology Urban areas Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution Water Pollutants, Chemical - toxicity Zebrafish Zebrafish - embryology |
| title | The pesticide malathion reduces survival and growth in developing zebrafish |
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