The Economic and Quality-of-Life Burden of Crohn’s Disease in Europe and the United States, 2000 to 2013: A Systematic Review
Background Crohn’s disease (CD) is associated with a substantial healthcare burden that affects the patient, healthcare systems and society in general. Aim To provide a systematic evaluation of published data relating to the economic and health-related quality-of-life (HRQoL) burden of CD in selecte...
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| Veröffentlicht in: | Digestive diseases and sciences 2015-02, Vol.60 (2), p.299-312 |
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| creator | Floyd, David N. Langham, Sue Séverac, Hélène Chevrou Levesque, Barrett G. |
| description | Background
Crohn’s disease (CD) is associated with a substantial healthcare burden that affects the patient, healthcare systems and society in general.
Aim
To provide a systematic evaluation of published data relating to the economic and health-related quality-of-life (HRQoL) burden of CD in selected European countries (Germany, France, UK, Italy, Spain) and the USA since 2000.
Methods
We undertook a systematic review of publications relating to CD, its economic burden and impact on HRQoL. Research questions focused on the disease costs from a societal perspective and HRQoL burden in adults and pediatric/adolescent patients according to disease stage/severity. Total, direct and indirect costs were identified, as well as the impact of CD on HRQoL measured using both generic and disease-specific instruments.
Results
Overall, 61 publications met the research criteria (38 on costs, 23 on HRQoL). CD in the USA and Europe together was associated with annual total costs of nearly €30 billion, more than half due to indirect costs. HRQoL was consistently and statistically significantly lower among CD patients compared with normal populations, due to physical, emotional and social effects.
Conclusions
CD is a global health problem with high societal costs and substantial HRQoL burden. High-value care pathways including cost-effective therapies will help to induce and maintain remission, reduce complications of disease and improve HRQoL. |
| doi_str_mv | 10.1007/s10620-014-3368-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1942221286</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712944098</galeid><sourcerecordid>A712944098</sourcerecordid><originalsourceid>FETCH-LOGICAL-c612t-e4e4cdeae0fd8f314894991ba19313b6400aa54aaa02d1e32b243a7eed1806c73</originalsourceid><addsrcrecordid>eNqFks1u1DAUhSMEokPhAdggS2xYkOJrO47DbhiGH2kkBG3Xlie5aV0l9tR2QNMNvAavx5PgYcqvQMiLa9nfOddXPkVxH-gRUFo_iUAloyUFUXIuVXl1o5hBVfOSVVLdLGYUZN4DyIPiTowXlNKmBnm7OGAVqxTlYlZ8PDlHsmy986NtiXEdeTuZwaZt6ftyZXskz6bQoSO-J4vgz92XT58jeW4jmojEOrKcgt_gN2XKVqfOJuzIcTIJ42PCck-SfK7An5I5Od7GhKNJudc7fG_xw93iVm-GiPeu62Fx-mJ5snhVrt68fL2Yr8pWAkslChRthwZp36meg1CNaBpYG2g48LUUlBpTCWMMZR0gZ2smuKkRO1BUtjU_LB7tfTfBX04Ykx5tbHEYjEM_RQ2NYIwBU_L_qKwYV0pxldGHf6AXfgouD5IpUVd1JWv-kzozA2rrep-CaXemel4Da4Sgzc7r6C9UXh3mr_EOe5vPfxPAXtAGH2PAXm-CHU3YaqB6lw-9z4fO-dC7fOirrHlw_eBpPWL3Q_E9EBlgeyDmK3eG4ZeJ_un6Ffg7wd0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1647575673</pqid></control><display><type>article</type><title>The Economic and Quality-of-Life Burden of Crohn’s Disease in Europe and the United States, 2000 to 2013: A Systematic Review</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Floyd, David N. ; Langham, Sue ; Séverac, Hélène Chevrou ; Levesque, Barrett G.</creator><creatorcontrib>Floyd, David N. ; Langham, Sue ; Séverac, Hélène Chevrou ; Levesque, Barrett G.</creatorcontrib><description>Background
Crohn’s disease (CD) is associated with a substantial healthcare burden that affects the patient, healthcare systems and society in general.
Aim
To provide a systematic evaluation of published data relating to the economic and health-related quality-of-life (HRQoL) burden of CD in selected European countries (Germany, France, UK, Italy, Spain) and the USA since 2000.
Methods
We undertook a systematic review of publications relating to CD, its economic burden and impact on HRQoL. Research questions focused on the disease costs from a societal perspective and HRQoL burden in adults and pediatric/adolescent patients according to disease stage/severity. Total, direct and indirect costs were identified, as well as the impact of CD on HRQoL measured using both generic and disease-specific instruments.
Results
Overall, 61 publications met the research criteria (38 on costs, 23 on HRQoL). CD in the USA and Europe together was associated with annual total costs of nearly €30 billion, more than half due to indirect costs. HRQoL was consistently and statistically significantly lower among CD patients compared with normal populations, due to physical, emotional and social effects.
Conclusions
CD is a global health problem with high societal costs and substantial HRQoL burden. High-value care pathways including cost-effective therapies will help to induce and maintain remission, reduce complications of disease and improve HRQoL.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-014-3368-z</identifier><identifier>PMID: 25258034</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Adult ; Age of Onset ; Biochemistry ; Child ; Child, Preschool ; Cost of Illness ; Crohn Disease - economics ; Crohn Disease - epidemiology ; Crohn Disease - psychology ; Crohn Disease - therapy ; Disease Progression ; Economic aspects ; Europe - epidemiology ; Gastroenterology ; Health Care Costs ; Health Expenditures ; Hepatology ; Humans ; Infant ; Infant, Newborn ; Medical care, Cost of ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Models, Economic ; Oncology ; Predictive Value of Tests ; Quality of Life ; Review ; Severity of Illness Index ; Surveys and Questionnaires ; Time Factors ; Transplant Surgery ; Treatment Outcome ; United States - epidemiology ; Young Adult</subject><ispartof>Digestive diseases and sciences, 2015-02, Vol.60 (2), p.299-312</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>COPYRIGHT 2015 Springer</rights><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c612t-e4e4cdeae0fd8f314894991ba19313b6400aa54aaa02d1e32b243a7eed1806c73</citedby><cites>FETCH-LOGICAL-c612t-e4e4cdeae0fd8f314894991ba19313b6400aa54aaa02d1e32b243a7eed1806c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-014-3368-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-014-3368-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25258034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Floyd, David N.</creatorcontrib><creatorcontrib>Langham, Sue</creatorcontrib><creatorcontrib>Séverac, Hélène Chevrou</creatorcontrib><creatorcontrib>Levesque, Barrett G.</creatorcontrib><title>The Economic and Quality-of-Life Burden of Crohn’s Disease in Europe and the United States, 2000 to 2013: A Systematic Review</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Crohn’s disease (CD) is associated with a substantial healthcare burden that affects the patient, healthcare systems and society in general.
Aim
To provide a systematic evaluation of published data relating to the economic and health-related quality-of-life (HRQoL) burden of CD in selected European countries (Germany, France, UK, Italy, Spain) and the USA since 2000.
Methods
We undertook a systematic review of publications relating to CD, its economic burden and impact on HRQoL. Research questions focused on the disease costs from a societal perspective and HRQoL burden in adults and pediatric/adolescent patients according to disease stage/severity. Total, direct and indirect costs were identified, as well as the impact of CD on HRQoL measured using both generic and disease-specific instruments.
Results
Overall, 61 publications met the research criteria (38 on costs, 23 on HRQoL). CD in the USA and Europe together was associated with annual total costs of nearly €30 billion, more than half due to indirect costs. HRQoL was consistently and statistically significantly lower among CD patients compared with normal populations, due to physical, emotional and social effects.
Conclusions
CD is a global health problem with high societal costs and substantial HRQoL burden. High-value care pathways including cost-effective therapies will help to induce and maintain remission, reduce complications of disease and improve HRQoL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Biochemistry</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cost of Illness</subject><subject>Crohn Disease - economics</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn Disease - psychology</subject><subject>Crohn Disease - therapy</subject><subject>Disease Progression</subject><subject>Economic aspects</subject><subject>Europe - epidemiology</subject><subject>Gastroenterology</subject><subject>Health Care Costs</subject><subject>Health Expenditures</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Medical care, Cost of</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Models, Economic</subject><subject>Oncology</subject><subject>Predictive Value of Tests</subject><subject>Quality of Life</subject><subject>Review</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>Time Factors</subject><subject>Transplant Surgery</subject><subject>Treatment Outcome</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFks1u1DAUhSMEokPhAdggS2xYkOJrO47DbhiGH2kkBG3Xlie5aV0l9tR2QNMNvAavx5PgYcqvQMiLa9nfOddXPkVxH-gRUFo_iUAloyUFUXIuVXl1o5hBVfOSVVLdLGYUZN4DyIPiTowXlNKmBnm7OGAVqxTlYlZ8PDlHsmy986NtiXEdeTuZwaZt6ftyZXskz6bQoSO-J4vgz92XT58jeW4jmojEOrKcgt_gN2XKVqfOJuzIcTIJ42PCck-SfK7An5I5Od7GhKNJudc7fG_xw93iVm-GiPeu62Fx-mJ5snhVrt68fL2Yr8pWAkslChRthwZp36meg1CNaBpYG2g48LUUlBpTCWMMZR0gZ2smuKkRO1BUtjU_LB7tfTfBX04Ykx5tbHEYjEM_RQ2NYIwBU_L_qKwYV0pxldGHf6AXfgouD5IpUVd1JWv-kzozA2rrep-CaXemel4Da4Sgzc7r6C9UXh3mr_EOe5vPfxPAXtAGH2PAXm-CHU3YaqB6lw-9z4fO-dC7fOirrHlw_eBpPWL3Q_E9EBlgeyDmK3eG4ZeJ_un6Ffg7wd0</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Floyd, David N.</creator><creator>Langham, Sue</creator><creator>Séverac, Hélène Chevrou</creator><creator>Levesque, Barrett G.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150201</creationdate><title>The Economic and Quality-of-Life Burden of Crohn’s Disease in Europe and the United States, 2000 to 2013: A Systematic Review</title><author>Floyd, David N. ; Langham, Sue ; Séverac, Hélène Chevrou ; Levesque, Barrett G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c612t-e4e4cdeae0fd8f314894991ba19313b6400aa54aaa02d1e32b243a7eed1806c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Biochemistry</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cost of Illness</topic><topic>Crohn Disease - economics</topic><topic>Crohn Disease - epidemiology</topic><topic>Crohn Disease - psychology</topic><topic>Crohn Disease - therapy</topic><topic>Disease Progression</topic><topic>Economic aspects</topic><topic>Europe - epidemiology</topic><topic>Gastroenterology</topic><topic>Health Care Costs</topic><topic>Health Expenditures</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Medical care, Cost of</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Models, Economic</topic><topic>Oncology</topic><topic>Predictive Value of Tests</topic><topic>Quality of Life</topic><topic>Review</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>Time Factors</topic><topic>Transplant Surgery</topic><topic>Treatment Outcome</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Floyd, David N.</creatorcontrib><creatorcontrib>Langham, Sue</creatorcontrib><creatorcontrib>Séverac, Hélène Chevrou</creatorcontrib><creatorcontrib>Levesque, Barrett G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Floyd, David N.</au><au>Langham, Sue</au><au>Séverac, Hélène Chevrou</au><au>Levesque, Barrett G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Economic and Quality-of-Life Burden of Crohn’s Disease in Europe and the United States, 2000 to 2013: A Systematic Review</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>60</volume><issue>2</issue><spage>299</spage><epage>312</epage><pages>299-312</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background
Crohn’s disease (CD) is associated with a substantial healthcare burden that affects the patient, healthcare systems and society in general.
Aim
To provide a systematic evaluation of published data relating to the economic and health-related quality-of-life (HRQoL) burden of CD in selected European countries (Germany, France, UK, Italy, Spain) and the USA since 2000.
Methods
We undertook a systematic review of publications relating to CD, its economic burden and impact on HRQoL. Research questions focused on the disease costs from a societal perspective and HRQoL burden in adults and pediatric/adolescent patients according to disease stage/severity. Total, direct and indirect costs were identified, as well as the impact of CD on HRQoL measured using both generic and disease-specific instruments.
Results
Overall, 61 publications met the research criteria (38 on costs, 23 on HRQoL). CD in the USA and Europe together was associated with annual total costs of nearly €30 billion, more than half due to indirect costs. HRQoL was consistently and statistically significantly lower among CD patients compared with normal populations, due to physical, emotional and social effects.
Conclusions
CD is a global health problem with high societal costs and substantial HRQoL burden. High-value care pathways including cost-effective therapies will help to induce and maintain remission, reduce complications of disease and improve HRQoL.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25258034</pmid><doi>10.1007/s10620-014-3368-z</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2015-02, Vol.60 (2), p.299-312 |
| issn | 0163-2116 1573-2568 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Age of Onset Biochemistry Child Child, Preschool Cost of Illness Crohn Disease - economics Crohn Disease - epidemiology Crohn Disease - psychology Crohn Disease - therapy Disease Progression Economic aspects Europe - epidemiology Gastroenterology Health Care Costs Health Expenditures Hepatology Humans Infant Infant, Newborn Medical care, Cost of Medical research Medicine Medicine & Public Health Medicine, Experimental Models, Economic Oncology Predictive Value of Tests Quality of Life Review Severity of Illness Index Surveys and Questionnaires Time Factors Transplant Surgery Treatment Outcome United States - epidemiology Young Adult |
| title | The Economic and Quality-of-Life Burden of Crohn’s Disease in Europe and the United States, 2000 to 2013: A Systematic Review |
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