Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients
Background The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive...
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creator | Achitei, D. Ciobica, A. Balan, G. Gologan, E. Stanciu, C. Stefanescu, G. |
description | Background
The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and the increased peroxidation of lipids, but patients in remission were generally not considered different from healthy people in terms of oxidative stress.
Aims
We evaluated the antioxidant defense capacity and lipid peroxidation status in the serum of patients with active and non-active disease compared with healthy matched control subjects.
Methods
The study included 20 patients with confirmed IBD in clinical and biological remission, 21 patients with active disease, and 18 controls. We determined the serum levels of two antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), and a lipid peroxidation marker, malondialdehyde (MDA).
Results
Active disease patients had an increased activity of both SOD and GPX, as well as significant high values of MDA versus controls. Furthermore, patients being in remission had significantly lower values of antioxidant enzymes (SOD and GPX) and increased lipid peroxidation measured by MDA serum levels, as compared with healthy control subjects.
Conclusions
Our study confirmed the presence of high oxidative stress in active IBD. More importantly, we have demonstrated a lower antioxidant capacity of patients in remission versus control group. This may represent a risk factor for the disease and can be an additional argument for the direct implication of oxidative stress in the pathogenesis of IBD. |
doi_str_mv | 10.1007/s10620-012-2510-z |
format | Article |
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The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and the increased peroxidation of lipids, but patients in remission were generally not considered different from healthy people in terms of oxidative stress.
Aims
We evaluated the antioxidant defense capacity and lipid peroxidation status in the serum of patients with active and non-active disease compared with healthy matched control subjects.
Methods
The study included 20 patients with confirmed IBD in clinical and biological remission, 21 patients with active disease, and 18 controls. We determined the serum levels of two antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), and a lipid peroxidation marker, malondialdehyde (MDA).
Results
Active disease patients had an increased activity of both SOD and GPX, as well as significant high values of MDA versus controls. Furthermore, patients being in remission had significantly lower values of antioxidant enzymes (SOD and GPX) and increased lipid peroxidation measured by MDA serum levels, as compared with healthy control subjects.
Conclusions
Our study confirmed the presence of high oxidative stress in active IBD. More importantly, we have demonstrated a lower antioxidant capacity of patients in remission versus control group. This may represent a risk factor for the disease and can be an additional argument for the direct implication of oxidative stress in the pathogenesis of IBD.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-012-2510-z</identifier><identifier>PMID: 23306840</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Antioxidants ; Biochemistry ; C-Reactive Protein - metabolism ; Case-Control Studies ; Comparative analysis ; Female ; Gastroenterology ; Gastrointestinal diseases ; Glutathione Peroxidase - metabolism ; Hepatology ; Humans ; Inflammatory bowel disease ; Inflammatory Bowel Diseases - enzymology ; Lipid Peroxidation ; Lipids ; Male ; Malondialdehyde - blood ; Medical colleges ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Oncology ; Original Article ; Oxidative Stress ; Peroxidase ; Prospective Studies ; Risk factors ; Superoxide ; Superoxide Dismutase - metabolism ; Transplant Surgery ; Young Adult</subject><ispartof>Digestive diseases and sciences, 2013-05, Vol.58 (5), p.1244-1249</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><rights>Springer Science+Business Media, LLC 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-519465b60dccb96020b2ecaae813ef59a859fb622045f35e63b8039fd371380c3</citedby><cites>FETCH-LOGICAL-c538t-519465b60dccb96020b2ecaae813ef59a859fb622045f35e63b8039fd371380c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-012-2510-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-012-2510-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23306840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Achitei, D.</creatorcontrib><creatorcontrib>Ciobica, A.</creatorcontrib><creatorcontrib>Balan, G.</creatorcontrib><creatorcontrib>Gologan, E.</creatorcontrib><creatorcontrib>Stanciu, C.</creatorcontrib><creatorcontrib>Stefanescu, G.</creatorcontrib><title>Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and the increased peroxidation of lipids, but patients in remission were generally not considered different from healthy people in terms of oxidative stress.
Aims
We evaluated the antioxidant defense capacity and lipid peroxidation status in the serum of patients with active and non-active disease compared with healthy matched control subjects.
Methods
The study included 20 patients with confirmed IBD in clinical and biological remission, 21 patients with active disease, and 18 controls. We determined the serum levels of two antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), and a lipid peroxidation marker, malondialdehyde (MDA).
Results
Active disease patients had an increased activity of both SOD and GPX, as well as significant high values of MDA versus controls. Furthermore, patients being in remission had significantly lower values of antioxidant enzymes (SOD and GPX) and increased lipid peroxidation measured by MDA serum levels, as compared with healthy control subjects.
Conclusions
Our study confirmed the presence of high oxidative stress in active IBD. More importantly, we have demonstrated a lower antioxidant capacity of patients in remission versus control group. This may represent a risk factor for the disease and can be an additional argument for the direct implication of oxidative stress in the pathogenesis of IBD.</description><subject>Adult</subject><subject>Antioxidants</subject><subject>Biochemistry</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Comparative analysis</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastrointestinal diseases</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases - enzymology</subject><subject>Lipid Peroxidation</subject><subject>Lipids</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Medical colleges</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Oxidative Stress</subject><subject>Peroxidase</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>Superoxide</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Transplant Surgery</subject><subject>Young Adult</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFks1u1DAUhSMEokPhAdggS2zYpFzbsZMsh_5ApRHMAtaW41wXV4k92Blg5gX62jid8isQ8sK-ut859pVPUTylcEIB6peJgmRQAmUlExTK_b1iQUXNcyWb-8UCqMxnSuVR8SilawBoayofFkeMc5BNBYvi5sxZixH9RNYxWDcgCZasMbrNR4x6IEs_ufDV9ToT536_GzER7XuychvXz-BtMzOeOE-WZnKf8RZ4G3ypD-Wlt4MeRz2FuCOvwhccyJlLqBOSdZbmy9Pj4oHVQ8Ind_tx8eHi_P3pm3L17vXl6XJVGsGbqRS0raToJPTGdK0EBh1DozU2lKMVrW5EazvJGFTCcoGSdw3w1va8prwBw4-LFwffTQyftpgmNbpkcBi0x7BNKvuzrG4q8X-Ui6puoWYso8__QK_DNvo8yExxAcAr_pO60gMq522YojazqVrWlM2TVTRTJ3-h8upxdCZ4nD_pdwE9CEwMKUW0ahPdqONOUVBzTtQhJyrnRM05UfuseXb34G03Yv9D8T0YGWAHIOWWv8L4y0T_dP0Go0_G0w</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Achitei, D.</creator><creator>Ciobica, A.</creator><creator>Balan, G.</creator><creator>Gologan, E.</creator><creator>Stanciu, C.</creator><creator>Stefanescu, G.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130501</creationdate><title>Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients</title><author>Achitei, D. ; Ciobica, A. ; Balan, G. ; Gologan, E. ; Stanciu, C. ; Stefanescu, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-519465b60dccb96020b2ecaae813ef59a859fb622045f35e63b8039fd371380c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Antioxidants</topic><topic>Biochemistry</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>Comparative analysis</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastrointestinal diseases</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory Bowel Diseases - enzymology</topic><topic>Lipid Peroxidation</topic><topic>Lipids</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Medical colleges</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Oxidative Stress</topic><topic>Peroxidase</topic><topic>Prospective Studies</topic><topic>Risk factors</topic><topic>Superoxide</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Transplant Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Achitei, D.</creatorcontrib><creatorcontrib>Ciobica, A.</creatorcontrib><creatorcontrib>Balan, G.</creatorcontrib><creatorcontrib>Gologan, E.</creatorcontrib><creatorcontrib>Stanciu, C.</creatorcontrib><creatorcontrib>Stefanescu, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Achitei, D.</au><au>Ciobica, A.</au><au>Balan, G.</au><au>Gologan, E.</au><au>Stanciu, C.</au><au>Stefanescu, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>58</volume><issue>5</issue><spage>1244</spage><epage>1249</epage><pages>1244-1249</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background
The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and the increased peroxidation of lipids, but patients in remission were generally not considered different from healthy people in terms of oxidative stress.
Aims
We evaluated the antioxidant defense capacity and lipid peroxidation status in the serum of patients with active and non-active disease compared with healthy matched control subjects.
Methods
The study included 20 patients with confirmed IBD in clinical and biological remission, 21 patients with active disease, and 18 controls. We determined the serum levels of two antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), and a lipid peroxidation marker, malondialdehyde (MDA).
Results
Active disease patients had an increased activity of both SOD and GPX, as well as significant high values of MDA versus controls. Furthermore, patients being in remission had significantly lower values of antioxidant enzymes (SOD and GPX) and increased lipid peroxidation measured by MDA serum levels, as compared with healthy control subjects.
Conclusions
Our study confirmed the presence of high oxidative stress in active IBD. More importantly, we have demonstrated a lower antioxidant capacity of patients in remission versus control group. This may represent a risk factor for the disease and can be an additional argument for the direct implication of oxidative stress in the pathogenesis of IBD.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23306840</pmid><doi>10.1007/s10620-012-2510-z</doi><tpages>6</tpages></addata></record> |
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subjects | Adult Antioxidants Biochemistry C-Reactive Protein - metabolism Case-Control Studies Comparative analysis Female Gastroenterology Gastrointestinal diseases Glutathione Peroxidase - metabolism Hepatology Humans Inflammatory bowel disease Inflammatory Bowel Diseases - enzymology Lipid Peroxidation Lipids Male Malondialdehyde - blood Medical colleges Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Oncology Original Article Oxidative Stress Peroxidase Prospective Studies Risk factors Superoxide Superoxide Dismutase - metabolism Transplant Surgery Young Adult |
title | Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients |
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