Curcumin Ameliorates Hydrogen Peroxide-Induced Epithelial Barrier Disruption by Upregulating Heme Oxygenase-1 Expression in Human Intestinal Epithelial Cells

Background Disruption of epithelial tight junctions (TJ) followed by loss of barrier function is of crucial importance in the pathogenesis of a variety of gastrointestinal disorders. Heme oxygenase-1 (HO-1), which can be induced by curcumin (Cur), provides protection against various forms of oxidati...

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Veröffentlicht in:	Digestive diseases and sciences 2012-07, Vol.57 (7), p.1792-1801
Hauptverfasser:	Wang, Na, Wang, Gai, Hao, JingXia, Ma, JunJi, Wang, Yan, Jiang, XiaoYu, Jiang, HuiQing
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biochemistry Caco-2 Cells Cell Line Cell Membrane Permeability - drug effects Cells, Cultured Curcumin - pharmacology Fluorescein Gastroenterology Gastrointestinal diseases Heme Heme Oxygenase-1 - metabolism Hepatology Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology In Vitro Techniques Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Medicine Medicine & Public Health Oncology Original Article Oxidative Stress - drug effects Permeability Proteins RNA Tight Junctions - drug effects Transplant Surgery Up-Regulation - drug effects
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